Prenylated Indole Alkaloid Derivatives from Marine Sediment-Derived Fungus Penicillium paneum SD-44

被引：17

作者：

Li, Chun-Shun ^{[1
]}

Li, Xiao-Ming ^{[1
]}

An, Chun-Yan ^{[1
]}

Wang, Bin-Gui ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China

来源：

HELVETICA CHIMICA ACTA | 2014年 / 97卷 / 10期

基金：

中国国家自然科学基金;

关键词：

Penicillium paneum; -Carbolines; Alkaloids; Indole alkaloids; NATURAL-PRODUCTS;

D O I：

10.1002/hlca.201400035

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Three new prenylated indole alkaloids, including two -carbolines, penipalines A and B (1 and 2, resp.), and one indole carbaldehyde derivative, penipaline C (3), as well as two known indole derived analogs, 4 and 5, were isolated from the deep-sea-sediment derived fungus Penicillium paneum SD-44 cultured in a 500-l bioreactor. The structures of the new compounds were determined on the basis of 1D- and 2D-NMR spectroscopy, as well as by high-resolution mass spectrometry. The new compounds 2 and 3 showed potent cytotoxic activities against A-549 and HCT-116 cell lines.

引用

页码：1440 / 1444

页数：5

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