Laser-produced Au nanoparticles as X-ray contrast agents for diagnostic imaging

被引：26
|
作者：
Torrisi, L. [1 ]
Restuccia, N. [1 ]
Cuzzocrea, S. [2 ]
Paterniti, I. [2 ]
Ielo, I. [3 ]
Pergolizzi, S. [4 ]
Cutroneo, M. [5 ]
Kovacik, L. [6 ]
机构：
[1] Univ Messina, MIFT, Dip Sci Fis, Vle FS Alcontres 31, I-98166 S Agata, ME, Italy
[2] Univ Messina, CBFA, Dip Sci Fis, Vle FS Alcontres 31, I-98166 S Agata, ME, Italy
[3] AOU Policlin Univ Messina, UOC Fis Sanit, VC Valeria 1, I-98125 Messina, Italy
[4] Univ Messina, Dip Sci Biomed Odontoiatriche & Immagini, Messina, Italy
[5] CAS, Inst Nucl Phys, Rez 25068, Czech Republic
[6] Charles Univ Prague, Fac Med 1, Inst Cellular Biol & Pathol, Albertov 4, Prague 12801, Czech Republic
来源：
GOLD BULLETIN | 2017年 / 50卷 / 01期
关键词：
Au nanoparticles; Laser; X-ray diagnostics; Medical imaging; Contrast medium; GOLD NANOPARTICLES; RADIOTHERAPY;
D O I：
10.1007/s13404-017-0195-y
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
We propose very promising gold nanoparticles for medicinal diagnostic and therapy. The synthesis of gold nanoparticles by using laser ablation in liquids and their physical characterization, jointed with their surface plasmon resonance absorptions, high density and atomic number, and high bio-compatibility, is presented in the first part of the article. The second part describes aspects of X-ray absorption enhancement due to the presence of gold nanoparticles in the biological liquids and tissues. The third part of the manuscript shows the applications of gold nanoparticles as contrast medium for X-ray diagnostic imaging. We also discuss possibilities of improvement of the radio therapeutic dose released to disease tissues, to which the gold nanoparticles can be locally absorbed, transported, or injected.
引用
收藏
页码：51 / 60
页数：10
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