Non-occlusive mesenteric ischemia during bevacizumab treatment for glioblastoma: a case report

被引：2

作者：

Oikawa, Nozomu ^{[1
]}

Kinoshita, Masashi ^{[1
]}

Yamamura, Minako ^{[2
]}

Uno, Takehiro ^{[1
]}

Ichinose, Toshiya ^{[1
]}

Sabit, Hemragul ^{[1
]}

Hayashi, Tomoyuki ^{[3
]}

Inoue, Dai ^{[4
]}

Harada, Kenichi ^{[2
]}

Nakada, Mitsutoshi ^{[1
]}

机构：

[1] Kanazawa Univ, Dept Neurosurg, 13-1 Takara Machi, Kanazawa, Ishikawa 9208641, Japan

[2] Kanazawa Univ, Dept Human Pathol, Grad Sch Med, Kanazawa, Ishikawa, Japan

[3] Kanazawa Univ, Dept Gastroenterol, Kanazawa, Ishikawa, Japan

[4] Kanazawa Univ, Dept Radiol, Kanazawa, Ishikawa, Japan

来源：

ACTA NEUROCHIRURGICA | 2022年 / 164卷 / 10期

关键词：

Bevacizumab; Glioblastoma; Non-occlusive mesenteric ischemia; THERAPY;

D O I：

10.1007/s00701-022-05328-1

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Glioblastoma is one of the most aggressive brain tumors in adults. The standard treatment is radiotherapy and chemotherapy based on the Stupp regimen after maximal safe resection. One effective chemotherapeutic drug is bevacizumab, which can prolong progression-free survival in glioblastoma patients but not overall survival. Adverse events of bevacizumab include hypertension, proteinuria, delayed wound healing, bleeding of the nose and gums, and thromboembolism resulting in gastrointestinal perforation. Herein, we describe an autopsy case of a patient with glioblastoma who died from non-occlusive mesenteric ischemia that was presumably caused by bevacizumab.

引用

页码：2767 / 2771

页数：5

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