Immunology of Inflammatory Bowel Disease: Molecular Mechanisms and Therapeutics

被引：79

作者：

Lu, Quan ^{[1
,2
]}

Yang, Mei-feng ^{[3
]}

Liang, Yu-jie ^{[4
]}

Xu, Jing ^{[5
]}

Xu, Hao-ming ^{[5
]}

Nie, Yu-qiang ^{[5
]}

Wang, Li-sheng ^{[1
,2
]}

Yao, Jun ^{[1
,2
]}

Li, De-feng ^{[1
,2
]}

机构：

[1] Jinan Univ, Shenzhen Peoples Hosp, Dept Gastroenterol, Clin Med Coll 2, Shenzhen, Guangdong, Peoples R China

[2] Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Dept Gastroenterol, Affiliated Hosp 1, Shenzhen, Guangdong, Peoples R China

[3] Yantian Dist Peoples Hosp, Dept Hematol, Shenzhen, Guangdong, Peoples R China

[4] Shenzhen Kangning Hosp, Dept Child & Adolescent Psychiat, Shenzhen, Guangdong, Peoples R China

[5] South China Univ Technol, Dept Gastroenterol & Hepatol, Sch Med, Guangzhou Peoples Hosp 1, Guangzhou, Guangdong, Peoples R China

来源：

JOURNAL OF INFLAMMATION RESEARCH | 2022年 / 15卷

基金：

中国国家自然科学基金;

关键词：

inflammatory bowel disease; immune system; immunological pathogenesis; immunotherapy; REGULATORY T-CELLS; ACTIVE ULCERATIVE-COLITIS; FECAL MICROBIOTA TRANSPLANTATION; ANTITUMOR NECROSIS FACTOR; TIGHT JUNCTION BARRIER; SEVERE CROHNS-DISEASE; DSS-INDUCED COLITIS; NF-KAPPA-B; INTESTINAL FIBROSIS; MAINTENANCE THERAPY;

D O I：

10.2147/JIR.S353038

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

As a main digestive organ and an important immune organ, the intestine plays a vital role in resisting the invasion of potential pathogens into the body. Intestinal immune dysfunction remains important pathogenesis of inflammatory bowel disease (IBD). In this review, we explained the interactions among symbiotic flora, intestinal epithelial cells, and the immune system, clarified the operating mechanism of the intestinal immune system, and highlighted the immunological pathogenesis of IBD, with a focus on the development of immunotherapy for IBD. In addition, intestinal fibrosis is a significant complication in patients with long-term IBD, and we reviewed the immunological pathogenesis involved in the development of intestinal fibrogenesis and provided novel antifibrotic immunotherapies for IBD.

引用

页码：1825 / 1844

页数：20

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