In vitro cytotoxicity of an endophytic fungus isolated from Nothapodytes foetida

被引：2
|
作者：
Rehman, Suriya [1 ]
Shawl, Abdul Sami [1 ]
Sultana, Sarvat [2 ]
Kouri, Arnardeep [1 ]
Riyaz-Ul-Hassan, Syed [3 ]
Qazi, Ghulam Nabi [3 ]
机构：
[1] Indian Inst Integrat Med CSIR, Srinagar 190005, Jammu & Kashmir, India
[2] Jamia Hamdard, New Delhi, India
[3] Indian Inst Integrat Med CSIR, Jammu, India
来源：
ANNALS OF MICROBIOLOGY | 2009年 / 59卷 / 01期
关键词：
Nothapodytes foetida; endophytes; cytotoxicity;
D O I：
10.1007/BF03175614
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
An attempt has been made to assess in vitro cytotoxicity of an endophytic fungus from Nothapodytes foetida. Various human cancer cell lines (liver HEP-2, lung A-549, ovary OVAR-5, prostate PC-3, cervix HeLa, colon HCT-15, oral cell line KB, CNS SNB-78, were used. In vitro cytotoxicity of camptothecin (CPT) isolated from the fungus was done where OVAR-5 cell line showed maximum inhibition and HEP-2 cell line was least sensitive with this compound. In vitro cytotoxicity of fractions/extracts from endophyte was carried out where ethyl acetate fraction showed sufficient growth inhibition against all the cell lines.
引用
收藏
页码：157 / 161
页数：5
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