In vitro cytotoxicity of an endophytic fungus isolated from Nothapodytes foetida

被引：2

作者：

Rehman, Suriya ^{[1
]}

Shawl, Abdul Sami ^{[1
]}

Sultana, Sarvat ^{[2
]}

Kouri, Arnardeep ^{[1
]}

Riyaz-Ul-Hassan, Syed ^{[3
]}

Qazi, Ghulam Nabi ^{[3
]}

机构：

[1] Indian Inst Integrat Med CSIR, Srinagar 190005, Jammu & Kashmir, India

[2] Jamia Hamdard, New Delhi, India

[3] Indian Inst Integrat Med CSIR, Jammu, India

来源：

ANNALS OF MICROBIOLOGY | 2009年 / 59卷 / 01期

关键词：

Nothapodytes foetida; endophytes; cytotoxicity;

D O I：

10.1007/BF03175614

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

An attempt has been made to assess in vitro cytotoxicity of an endophytic fungus from Nothapodytes foetida. Various human cancer cell lines (liver HEP-2, lung A-549, ovary OVAR-5, prostate PC-3, cervix HeLa, colon HCT-15, oral cell line KB, CNS SNB-78, were used. In vitro cytotoxicity of camptothecin (CPT) isolated from the fungus was done where OVAR-5 cell line showed maximum inhibition and HEP-2 cell line was least sensitive with this compound. In vitro cytotoxicity of fractions/extracts from endophyte was carried out where ethyl acetate fraction showed sufficient growth inhibition against all the cell lines.

引用

页码：157 / 161

页数：5

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