Preclinical Investigation of a Potent Geranylgeranyl Diphosphate Synthase Inhibitor

被引：0
|
作者：
Haney, Staci L.
Chhonker, Yashpal S.
Varney, Michelle L.
Talmon, Geoffrey A.
Murry, Daryl J.
Holstein, Sarah A.
机构：
来源：
BLOOD | 2017年 / 130卷
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
4625
引用
收藏
页数：2
相关论文
共 50 条
  • [21] Characterization of Potential Drug Targets Farnesyl Diphosphate Synthase and Geranylgeranyl Diphosphate Synthase in Schistosoma mansoni
    Ziniel, Peter D.
    Desai, Janish
    Cass, Cynthia L.
    Gatto, Craig
    Oldfield, Eric
    Williams, David L.
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2013, 57 (12) : 5969 - 5976
  • [22] Human geranylgeranyl diphosphate synthase - cDNA cloning and expression
    Kuzuguchi, T
    Morita, Y
    Sagami, I
    Sagami, H
    Ogura, K
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (09) : 5888 - 5894
  • [23] In Vivo Evaluation of Novel Geranylgeranyl Diphosphate Synthase Inhibitors
    Haney, Staci L.
    Chhonker, Yashpal S.
    Varney, Michelle L.
    Talmon, Geoffrey A.
    Murry, Daryl J.
    Holstein, Sarah A.
    BLOOD, 2018, 132
  • [24] Bishomoisoprenoid triazole bisphosphonates as inhibitors of geranylgeranyl diphosphate synthase
    Wills, Veronica S.
    Metzger, Joseph I.
    Allen, Cheryl
    Varney, Michelle L.
    Wiemer, David F.
    Holstein, Sarah A.
    BIOORGANIC & MEDICINAL CHEMISTRY, 2017, 25 (08) : 2437 - 2444
  • [25] Specificity of geranylgeranyl diphosphate synthase for homoallylic substrate analogs
    Ohya, Norimasa
    Ichijo, Takumi
    Sato, Hana
    Nakamura, Takeshi
    Yokota, Saki
    Sagami, Hiroshi
    Nagaki, Masahiko
    JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 2015, 120 : 179 - 182
  • [26] New series of bisphosphonate inhibitors of geranylgeranyl diphosphate synthase
    Foust, Benjamin
    Allen, Cheryl
    Holstein, Sarah
    Wiemer, David
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 251
  • [27] Identification and characterization of the geranylgeranyl diphosphate synthase in Deinococcus radiodurans
    Liu, C.
    Sun, Z.
    Shen, S.
    Lin, L.
    Li, T.
    Tian, B.
    Hua, Y.
    LETTERS IN APPLIED MICROBIOLOGY, 2014, 58 (03) : 219 - 224
  • [28] The anti-osteoclastic effects of the novel geranylgeranyl diphosphate synthase inhibitor RAM2061
    Muehlebach, Molly
    Holstein, Sarah
    Chonker, Yashpal
    Murry, D. J.
    JOURNAL OF BONE AND MINERAL RESEARCH, 2023, 38 : 223 - 223
  • [29] Maize cDNAs expressed in endosperm encode functional farnesyl diphosphate synthase with geranylgeranyl diphosphate synthase activity
    Cervantes-Cervantes, M
    Gallagher, CE
    Zhu, CF
    Wurtzel, ET
    PLANT PHYSIOLOGY, 2006, 141 (01) : 220 - 231
  • [30] Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate
    Gabriel, Heloisa B.
    Azevedo, Mauro F.
    Kimura, Emilia A.
    Katzin, Alejandro M.
    MEMORIAS DO INSTITUTO OSWALDO CRUZ, 2018, 113 (10):
12345