Drug self-templated synthesis of ibuprofen/mesoporous silica for sustained release

被引：43
|
作者：
Qu, Fengyu
Zhu, Guangshan [1 ]
Lin, Huiming
Sun, Jinyu
Zhang, Daliang
Li, Shougui
Qiu, Shilun
机构：
[1] Jilin Univ, State Key Lab Inorgan Synth & Preparat & Chem, Changchun 130023, Peoples R China
[2] Harbin Normal Univ, Dept Chem, Harbin 150080, Peoples R China
来源：
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2006年 / 19期
关键词：
template synthesis; ibuprofen; mesoporous materials; silica;
D O I：
10.1002/ejic.200501035
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The synthesis of Ibuprofen/mesoporous silica has been achieved by a drug self-templated one-step co-condensation process. The drug template of Ibuprofen, a co-template of 3-aminopropyltriethoxysilane (APTES), and tetraethoxysiliane (TEOS) were self-assembled into Ibuprofen/mesoporous silica in a neutral aqueous reaction system. This drug/mesoporous silica was characterized by powder XRD diffraction, FTIR spectroscopy, N-2 adsorption/desorption, TEM, and Si-29/ MAS and C-13/MAS NMR spectroscopy. The Ibuprofen/mesoporous silica system gives a well-sustained release profile.
引用
收藏
页码：3943 / 3947
页数：5
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