Synthetic studies toward the marine metabolite prorocentin-4: synthesis of the C1-C23 fragment

被引：3
|
作者：
AnkiReddy, Praveen [1 ]
AnkiReddy, Sandeep [1 ]
Gowravaram, Sabitha [1 ]
机构：
[1] Indian Inst Chem Technol, CSIR, Nat Prod Chem Div, Hyderabad 500607, India
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2018年 / 16卷 / 22期
关键词：
ASYMMETRIC EPOXIDATION; ALCOHOLS; POLYKETIDE;
D O I：
10.1039/c8ob00388b
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A synthetic study of the construction of the C1-C23 fragment of prorocentin-4, a novel linear polyketide, is described. The synthetic highlights include the acid catalyzed epoxide opening, Gilman reaction, Pd(OH)(2) catalyzed transformation of a primary propargylic alcohol into an aldehyde, Oxa-Michael cyclization, and Horner-Wadsworth-Emmons (HWE) olefination reaction as key steps.
引用
收藏
页码：4191 / 4194
页数：4
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