Array synthesis of progesterone receptor antagonists: 3-Aryl-1,2-diazepines

被引：14

作者：

Wiethe, Robert W. ^{[1
]}

Stewart, Eugene L. ^{[1
]}

Drewry, David H. ^{[1
]}

Gray, David W. ^{[1
]}

Mehbob, Abdul ^{[1
]}

Hoekstra, William J. ^{[1
]}

机构：

[1] GlaxoSmithKline Inc, Discovery Res, Res Triangle Pk, NC 27709 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 14期

关键词：

progesterone receptor; diazepine;

D O I：

10.1016/j.bmcl.2006.04.055

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

New non-steroidal chemotypes are required for the development of drugs targeting the steroid hormone receptors. The parallel array synthesis of 3-aryl-1,2-diazepines employing solid-supported reagents is described. The resulting compounds demonstrated high affinity binding to the progesterone receptor. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：3777 / 3779

页数：3

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