Array synthesis of progesterone receptor antagonists: 3-Aryl-1,2-diazepines

被引：14
|
作者：
Wiethe, Robert W. [1 ]
Stewart, Eugene L. [1 ]
Drewry, David H. [1 ]
Gray, David W. [1 ]
Mehbob, Abdul [1 ]
Hoekstra, William J. [1 ]
机构：
[1] GlaxoSmithKline Inc, Discovery Res, Res Triangle Pk, NC 27709 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 14期
关键词：
progesterone receptor; diazepine;
D O I：
10.1016/j.bmcl.2006.04.055
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
New non-steroidal chemotypes are required for the development of drugs targeting the steroid hormone receptors. The parallel array synthesis of 3-aryl-1,2-diazepines employing solid-supported reagents is described. The resulting compounds demonstrated high affinity binding to the progesterone receptor. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3777 / 3779
页数：3
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