Synthesis and Characterization of Two Impurities in Esomeprazole, an Antiulcerative Drug

被引：0
|
作者：
Liu, Xiao-ping [1 ,2 ]
Xu, Hui-lan [1 ]
Sun, Rui [2 ]
Li, Xue [1 ]
Hu, Bao-hua [2 ]
Hu, Chun [1 ,2 ]
机构：
[1] Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Peoples R China
[2] Yantai Valiant Fine Chem Co Ltd, Yantai 264006, Peoples R China
来源：
LATIN AMERICAN JOURNAL OF PHARMACY | 2015年 / 34卷 / 06期
基金：
美国国家科学基金会;
关键词：
characterization; esomeprazole; impurity; synthesis;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Impurity control is a key factor for drug quality. Study for impurities is helpful to optimize the production process and improve the quality of drugs. Synthesis and characterization of two of impurities in esomeprazole, which used for treatment of acid-related diseases was described in this paper. The two impurities are known as 2-[(3,5-dimethyl-4-methoxy-2-pyridinyl) methylsulfinyl]-1H-benzimidazole (impurity 1) and (R)-5-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl) methylsulfinyl]-1H-benzimidazole (esomeprazole impurity F), whose structures are characterized with MS, IR, H-1-NMR and elemental analyses, and the purities of the two impurities are above 99% by HPLC analysis. The two target compounds can be used as the reference substance of the impurities of esomeprazole.
引用
收藏
页码：1265 / 1268
页数：4
相关论文
共 50 条
  • [41] SYNTHESIS AND CHARACTERIZATION OF POTENTIAL IMPURITIES OF ARIPIPRAZOLE
    Verdia, Jitendra
    Kumar, Pankaj
    Joshi, Narendra S.
    INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2014, 5 (09): : 4046 - 4050
  • [42] Identification, characterization and synthesis of impurities of zafirlukast
    Goverdhan, Gilla
    Reddy, Anumula Raghupathi
    Srinivas, Kurella
    Himabindu, Vurimidi
    Reddy, Ghanta Mahesh
    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2009, 49 (04) : 895 - 900
  • [43] SYNTHESIS AND CHARACTERIZATION OF POTENTIAL IMPURITIES OF DEFERASIROX
    Joshi, Narendra
    Verdia, Jitendra
    Pandya, Jugal
    Dave, Hitesh
    Patel, Ketan
    HETEROCYCLIC LETTERS, 2014, 4 (01): : 85 - 92
  • [44] Synthesis and Characterization of Potential Impurities of Canagliflozin
    Pachore, Sharad S.
    Akula, Swapna
    Aaseef, Mohammad
    Jyothi, Mudumbai Usha
    Vemuri, Sasikala
    Prakash, Lakki Reddy
    Vidavulur, Siddaiah
    Sonawane, Swapnil P.
    Kumar, Unniar K. Syam
    Dahanukar, Vilas H.
    CHEMISTRYSELECT, 2017, 2 (28): : 9157 - 9161
  • [45] Antiepileptic Drug Rufinamide: Synthesis and Process Impurities
    Kumari, Mayuri
    Bansal, Vikas
    Alenazi, Fahaad
    Tripathy, Divya Bajpai
    Gupta, Anjali
    Singh, Vikram
    Yadav, Ishu
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2024, 60 (05) : 903 - 911
  • [46] An Efficient Synthesis of Darunavir Substantially Free from Impurities: Synthesis and Characterization of Novel Impurities
    Rapolu, Rajesh Kumar
    Areveli, Srinivas
    Raju, V. V. N. K. V. Prasada
    Navuluri, Srinivasu
    Chavali, Murthy
    Mulakayala, Naveen
    CHEMISTRYSELECT, 2019, 4 (14): : 4422 - 4427
  • [47] Esomeprazole fixed drug eruption
    Salloum, Antoine
    Nasr, Dayana
    Maalouf, Diane
    CONTACT DERMATITIS, 2020, 82 (05) : 334 - 335
  • [48] Synthesis of the impurities during the manufacture of bulk drug midazolam and separation of these impurities by HPLC
    Sati, Bhawana
    Sati, Hemlata
    Saklani, Sarla
    Ellamma
    Bhatt, Prakash Chandra
    Mishra, Ravinesh
    ACTA PHARMACEUTICA, 2013, 63 (03) : 385 - 396
  • [49] Asymmetric synthesis of esomeprazole
    Cotton, H
    Elebring, T
    Larsson, M
    Li, L
    Sörensen, H
    von Unge, S
    TETRAHEDRON-ASYMMETRY, 2000, 11 (18) : 3819 - 3825
  • [50] Synthesis and Characterization of Potential and Degraded Impurities of Regadenoson
    Sathiyanarayanan, Singaram
    Venkatesan, Chidambaram Subramanian
    Kabilan, Senthamaraikannan
    CURRENT PHARMACEUTICAL ANALYSIS, 2020, 16 (08) : 1130 - 1139
12345