Immunohistochemical characterization of 53 monoclonal antibodies to prostate-specific antigen

被引：1
|
作者：
Nap, M
van der Kwast, TM
机构：
[1] De Wever Hosp, Dept Pathol, Heerlen, Netherlands
[2] Erasmus Univ, Dept Pathol 1, Rotterdam, Netherlands
来源：
TUMOR BIOLOGY | 1999年 / 20卷
关键词：
prostate-specific antigen; ISOBM TD-3 Workshop; immunohistochemistry; antibodies;
D O I：
10.1159/000056529
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Fifty-three antibodies submitted to the ISOBM TD-3 Workshop on the prostate specific antigen (PSA) were evaluated for their reactivity in frozen and formalin fixed tissue from benign hyperplastic prostate and salivary gland tissue. Only 13/53 antibodies showed clear reactivity in both frozen and paraffin sections, while some antibodies appeared to react only in formalin-fixed paraffin sections. Many antibodies showed extensive nonspecific reactivity in tissue sections. These results highlight the fact that the number of monoclonal antibodies suitable for immunohistochemical detection of PSA is still relatively limited.
引用
收藏
页码：38 / 42
页数：5
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