Solubility of aspirin in supercritical carbon dioxide with and without acetone

被引：111
|
作者：
Huang, Z
Lu, WD
Kawi, S
Chiew, YC [1 ]
机构：
[1] Rutgers State Univ, Dept Chem & Biochem Engn, Piscataway, NJ 08854 USA
[2] Natl Univ Singapore, Dept Chem & Environm Engn, Singapore 119260, Singapore
来源：
JOURNAL OF CHEMICAL AND ENGINEERING DATA | 2004年 / 49卷 / 05期
关键词：
D O I：
10.1021/je0499465
中图分类号：
O414.1 [热力学];
学科分类号：
摘要：
The equilibrium solubility of aspirin in supercritical CO2 has been determined using a dynamic method. Measurements were performed at pressures ranging from (10 to 25) MPa and temperatures from (308.15 to 328.15) K. The effect of a polar cosolvent, acetone, on the solubility of aspirin in supercritical carbon dioxide was also studied. The results show that the addition of acetone produces up to a 5-fold increase in the aspirin solubility. The solubility of aspirin in CO2 is well described by the Peng-Robinson equation of state and density based correlations over the pressure and temperature ranges studied.
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收藏
页码：1323 / 1327
页数：5
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