Ruthenium-Catalyzed Switchable N-H/C-H Alkenylation of 6-Phenyl(dihydro)pyridazinones with Alkynes

被引：15

作者：

Wang, Wei ^{[1
]}

Liang, Lei ^{[1
]}

Xu, Fengrong ^{[1
]}

Huang, Wenjie ^{[1
]}

Niu, Yan ^{[1
]}

Sun, Qi ^{[1
]}

Xu, Ping ^{[1
]}

机构：

[1] Peking Univ, Dept Med Chem, Sch Pharmaceut Sci, Hlth Sci Ctr, Beijing 100191, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 2014卷 / 31期

基金：

中国国家自然科学基金; 高等学校博士学科点专项科研基金;

关键词：

Nitrogen heterocycles; Alkenylation; Alkynes; Ruthenium; Switchable reactions; INTRAMOLECULAR HYDROAMINATION; INTERMOLECULAR HYDROAMINATION; REGIOSELECTIVE HYDROAMINATION; PYRIDAZINONE DERIVATIVES; BOND FUNCTIONALIZATION; ANTIPLATELET ACTIVITY; CARDIOTONIC AGENTS; POTENT; HYDROARYLATION; ALKENES;

D O I：

10.1002/ejoc.201402986

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A ruthenium-catalyzed switchable N-H/C-H alkenylation reaction of 6-phenyl-(dihydro) pyridazin-3(2H)-ones triggered by a nitrogen/oxygen atmosphere was developed. To achieve switchable modification of the two important sites of the widely used pharmacophore, a simple and efficient procedure containing two optimized ruthenium catalytic systems was utilized, which afforded excellent activity, high selectivity, and good tolerance of a wide range of functional groups.

引用

页码：6863 / 6867

页数：5

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