Current Status of Urinary Biomarkers for Detection and Surveillance of Bladder Cancer

被引：67

作者：

Mbeutcha, Aurelie ^{[1
,2
]}

Lucca, Ilaria ^{[1
,3
]}

Mathieu, Romain ^{[1
,4
]}

Lotan, Yair ^{[5
]}

Shariat, Shahrokh F. ^{[1
,5
,6
]}

机构：

[1] Med Univ Vienna, Vienna Gen Hosp, Ctr Comprehens Canc, Dept Urol, A-1090 Vienna, Austria

[2] Univ Nice Sophia Antipolis, CHU Nice, Hop Archet 2, Dept Urol, F-06200 Nice, France

[3] CHU Vaudois, Dept Urol, CH-1010 Lausanne, Switzerland

[4] Rennes Univ Hosp, Dept Urol, F-35000 Rennes, France

[5] Univ Texas SW Med Ctr Dallas, Dept Urol, Dallas, TX 75235 USA

[6] Cornell Univ, Weill Cornell Med Coll, Dept Urol, New York, NY 10011 USA

来源：

UROLOGIC CLINICS OF NORTH AMERICA | 2016年 / 43卷 / 01期

关键词：

TRANSITIONAL-CELL CARCINOMA; IN-SITU HYBRIDIZATION; COMPLEMENT FACTOR-H; NUCLEAR-MATRIX PROTEIN-22; INVASIVE UROTHELIAL CARCINOMA; TRANSCRIPTASE MESSENGER-RNA; POLYMERASE-CHAIN-REACTION; PRIMARY-CARE PHYSICIANS; VOIDED-URINE; FOLLOW-UP;

D O I：

10.1016/j.ucl.2015.08.005

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The standard of care for detection and surveillance of bladder cancer consists of cytology and cystoscopy, but both examinations suffer from many limitations, including issues related to accuracy, invasiveness, and cost. Several noninvasive methods for detection and surveillance of bladder cancer have been developed and urine-based biomarkers seem the most promising. This nonsystematic review critically analyzes the commercially available biomarkers and highlights some upcoming investigational biomarkers. To date, none of these biomarkers has sufficient validation to serve as a reliable alternative to cystoscopy.

引用

页码：47 / +

页数：17

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