Limonoids from the Seeds of Swietenia macrophylla and Their Anti-Inflammatory Activities

被引：27

作者：

Chen, Li-Chai ^{[1
,2
]}

Liao, Hsiang-Ruei ^{[3
]}

Chen, Pei-Yu ^{[2
]}

Kuo, Wen-Lung ^{[4
]}

Chang, Tsung-Hsien ^{[5
]}

Sung, Ping-Jyun ^{[6
]}

Wen, Zhi-Hong ^{[1
]}

Chen, Jih-Jung ^{[7
,8
]}

机构：

[1] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Asia Pacific Ocean Res Ctr, Kaohsiung 80424, Taiwan

[2] Kaohsiung Armed Forces Gen Hosp, Dept Pharm, Zuoying Branch, Kaohsiung 81342, Taiwan

[3] Chang Gung Univ, Grad Inst Nat Prod, Sch Tradit Chinese Med, Coll Med, Taoyuan 33302, Taiwan

[4] Chung Jen Jr Coll Nursing Hlth Sci & Management, Chiayi 60077, Taiwan

[5] Kaohsiung Vet Gen Hosp, Dept Med Educ & Res, Kaohsiung 813, Taiwan

[6] Natl Museum Marine Biol & Aquarium, Pingtung 944, Taiwan

[7] Tajen Univ, Dept Pharm, Pingtung 90741, Taiwan

[8] Tajen Univ, Grad Inst Pharmaceut Technol, Pingtung 90741, Taiwan

来源：

MOLECULES | 2015年 / 20卷 / 10期

关键词：

Swietenia macrophylla; Meliaceae; structure elucidation; limonoid; anti-inflammatory activity; PHRAGMALIN-TYPE; MAHAGONI JACQ; CONSTITUENTS; NEUTROPHILS; SESQUITERPENE; DERIVATIVES; FRUITS;

D O I：

10.3390/molecules201018551

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new limonoid, swietemacrophin (1), was isolated from the seeds of Swietenia macrophylla, together with five known compounds 2-6. The structure of 1 was determined through extensive 1D/2D-NMR and mass-spectrometric analyses. Swietemacrophin (1), humilinolide F (2), 3,6-O,O-diacetylswietenolide (3), 3-O-tigloylswietenolide (4), and swietemahonin E (5) exhibited inhibition (IC50 values 45.44 M) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP). Compounds 1, 4, 5, and swietenine (6) showed potent inhibition with IC50 values 36.32 M, against lipopolysaccharide (LPS)-induced nitric oxide (NO) generation.

引用

页码：18551 / 18564

页数：14

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