An experimental study of preventing and treating acute radioactive enteritis with human umbilical cord mesenchymal stem cells

被引：5
|
作者：
Wang, Rui [1 ]
Yuan, Wei [2 ]
Zhao, Qiang [2 ]
Song, Peng [2 ]
Yue, Ji [1 ]
Lin, Shi-De [1 ]
Zhao, Ting-Bao [1 ]
机构：
[1] Jinan Mil Gen Hosp, Jinan 250000, Shandong, Peoples R China
[2] Peoples Hosp Zhangqiu, Zhangqiu, Shandong, Peoples R China
来源：
ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE | 2013年 / 6卷 / 12期
关键词：
Radioactive contamination; Human umbilical cord mesenchymal stem cells; Acute radioactive enteritis; Rat;
D O I：
10.1016/S1995-7645(13)60173-X
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Objective: To test the curative effect of human umbilical cord derived mesenchymal stem cells on rat acute radioactive enteritis and thus to provide clinical therapeutic basis for radiation sickness. Methods: Human umbilical cord derived mesenchymal stem cells were cultivated in vitro and the model of acute radioactive enteritis of rats was established. Then, the umbilical cord mesenchymal stem cells were injected into the rats via tail vein. Visual and histopathological changes of the experimental rats were observed. Results: After the injection, the rats in the prevention group and treatment group had remarkably better survival status than those in the control group. The histological observations revealed that the former also had better intestinal mucosa structure, more regenerative cells and stronger proliferation activity than the latter. Conclusions: Human umbilical cord derived mesenchymal stem cells have a definite therapeutic effect on acute radioactive enteritis in rats.
引用
收藏
页码：968 / 971
页数：4
相关论文
共 50 条
  • [21] Human Umbilical Cord-Derived Mesenchymal Stem Cells for Acute Respiratory Distress Syndrome
    Yip, Hon-Kan
    Fang, Wen-Feng
    Li, Yi-Chen
    Lee, Fan-Yen
    Lee, Chen-Hsiang
    Pei, Sung-Nan
    Ma, Ming-Chun
    Chen, Kuan-Hung
    Sung, Pei-Hsun
    Lee, Mel S.
    CRITICAL CARE MEDICINE, 2020, 48 (05) : E391 - E399
  • [22] Mesenchymal stem cells from bone marrow and umbilical cord for treating cardiovascular diseases
    Hidalgo Diaz, Jose R.
    Hernandez Canero, Alberto
    Chachques, Juan C.
    Paredes Cordero, Angel
    CORSALUD, 2018, 10 (01): : 47 - 51
  • [23] EFFICACY AND SAFETY OF UMBILICAL CORD-MESENCHYMAL STEM CELLS TRANSPLANTATION FOR TREATING OSTEOARTHRITIS
    Liu, C.
    Yang, Y.
    He, G.
    OSTEOARTHRITIS AND CARTILAGE, 2017, 25 : S389 - S389
  • [24] Differentiation of human umbilical cord mesenchymal stem cells into steroidogenic cells in vitro
    Xing, Xiaoyu
    Zhang, Zhiyuan
    Zhong, Liang
    Ju, Guanqun
    Zou, Xiangyu
    Zhu, Yingjian
    Sun, Jie
    EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2016, 12 (06) : 3527 - 3534
  • [25] Umbilical cord blood mesenchymal stem cells
    Musina, R. A.
    Bekchanova, E. S.
    Belyavskii, A. V.
    Grinenko, T. S.
    Sukhikh, G. T.
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2007, 143 (01) : 127 - 131
  • [26] Effectiveness and safety of human umbilical cord-mesenchymal stem cells for treating type 2 diabetes mellitus
    Lian, Xiao-Fen
    Lu, Dong-Hui
    Liu, Hong-Li
    Liu, Yan-Jing
    Han, Xiu-Qun
    Yang, Yang
    Lin, Yuan
    Zeng, Qing-Xiang
    Huang, Zheng-Jie
    Xie, Feng
    Huang, Cai-Hao
    Wu, Hong-Mei
    Long, Ai-Mei
    Deng, Ling-Ping
    Zhang, Fan
    WORLD JOURNAL OF DIABETES, 2022, 13 (10) : 877 - 887
  • [27] Umbilical cord blood mesenchymal stem cells
    R. A. Musina
    E. S. Bekchanova
    A. V. Belyavskii
    T. S. Grinenko
    G. T. Sukhikh
    Bulletin of Experimental Biology and Medicine, 2007, 143 : 127 - 131
  • [28] Isolation of mesenchymal stem cells from human umbilical cord blood
    Abolhassani, S.
    Yavari, K.
    JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2014, 8 : 308 - 308
  • [29] CHARACTERIZATION OF MESENCHYMAL STEM CELLS ISOLATED FROM HUMAN UMBILICAL CORD
    Moretti, P.
    Hatlapatka, T.
    Majore, I.
    Scheper, T.
    CYTOMETRY PART B-CLINICAL CYTOMETRY, 2008, 74B (06) : 381 - 381
  • [30] Human Umbilical Cord Mesenchymal Stem Cells Support Nontumorigenic Expansion of Human Embryonic Stem Cells
    Ding, Dah-Ching
    Shyu, Woei-Cherng
    Lin, Shinn-Zong
    Liu, Hwan-Wun
    Chiou, Shih-Hwa
    Chu, Tang-Yuan
    CELL TRANSPLANTATION, 2012, 21 (07) : 1515 - 1527
12345