Individualization of post-mastectomy radiotherapy and regional nodal irradiation based on treatment response after neoadjuvant chemotherapy for breast cancer

被引：1

作者：

Krug, David ^{[1
,2
]}

Baumann, Rene ^{[3
]}

Budach, Wilfried ^{[4
]}

Dunst, Juergen ^{[3
]}

Feyer, Petra ^{[5
]}

Fietkau, Rainer ^{[6
]}

Haase, Wulf ^{[7
]}

Harms, Wolfgang ^{[8
]}

Hehr, Thomas ^{[9
]}

Piroth, Marc D. ^{[10
]}

Sedlmayer, Felix ^{[11
]}

Souchon, Rainer ^{[12
]}

Wenz, Frederik ^{[13
]}

Sauer, Rolf ^{[6
]}

机构：

[1] Univ Hosp Heidelberg, Dept Radiat Oncol, Neuenheimer Feld 400, D-69120 Heidelberg, Germany

[2] Natl Ctr Radiat Res Oncol NCRO, Heidelberg Inst Radiat Oncol, Heidelberg, Germany

[3] Univ Hosp Schleswig Holstein, Kiel, Germany

[4] Heinrich Heine Univ, Dusseldorf, Germany

[5] Vivantes Hosp Neukoelln, Berlin, Germany

[6] Univ Hosp Erlangen, Erlangen, Germany

[7] St Vincentius Hosp, Karlsruhe, Germany

[8] St Clara Hosp, Basel, Switzerland

[9] Marienhosp Stuttgart, Dept Radiat Oncol, Stuttgart, Germany

[10] Witten Herdecke Univ, HELIOS Hosp Wuppertal, Wuppertal, Germany

[11] Paracelsus Med Univ Hosp, Salzburg, Austria

[12] Univ Hosp Tuebingen, Tubingen, Germany

[13] Heidelberg Univ, Univ Med Mannheim, Med Fak Mannheim, D-GRID77000 Mannheim, Germany

来源：

STRAHLENTHERAPIE UND ONKOLOGIE | 2018年 / 194卷 / 07期

关键词：

Local recurrence; Neoadjuvant therapy; Breast neoplasms; Radiotherapy; INTERNATIONAL EXPERT PANEL; DEGRO PRACTICAL GUIDELINES; SURGICAL ADJUVANT BREAST; TUMORS; 5; CM; STAGE-II; RADIATION-THERAPY; LOCOREGIONAL RECURRENCE; SYSTEMIC TREATMENT; LYMPH-NODES; MULTICENTER;

D O I：

10.1007/s00066-018-1270-x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To review the evidence regarding post-mastectomy radiotherapy (PMRT) and regional nodal irradiation (RNI) after neoadjuvant chemotherapy (NACT) for breast cancer, with a special focus on individualization of adjuvant radiotherapy based on treatment response. A systematic literature search using the PubMed/Medline database was performed. We included prospective and retrospective reports with a minimum of 10 patients that had been published since 1(st) January 2000, and provided clinical outcome data analyzed by treatment response and radiotherapy. Out of 763 articles identified via PubMed/Medline and hand search, 68 full text-articles were assessed for eligibility after screening of title and abstract. 13 studies were included in the systematic review, 9 for PMRT and 5 for RNI. All included studies were retrospective reports. There is a considerable lack of evidence regarding the role of adjuvant radiotherapy and its individualization based on treatment response after NACT. Results of prospective randomized trials such as NSABP BaEuro51/RTOG 1304 and Alliance A11202 are eagerly awaited.

引用

页码：607 / 618

页数：12

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