Individualization of post-mastectomy radiotherapy and regional nodal irradiation based on treatment response after neoadjuvant chemotherapy for breast cancer

被引：1

作者：

Krug, David ^{[1
,2
]}

Baumann, Rene ^{[3
]}

Budach, Wilfried ^{[4
]}

Dunst, Juergen ^{[3
]}

Feyer, Petra ^{[5
]}

Fietkau, Rainer ^{[6
]}

Haase, Wulf ^{[7
]}

Harms, Wolfgang ^{[8
]}

Hehr, Thomas ^{[9
]}

Piroth, Marc D. ^{[10
]}

Sedlmayer, Felix ^{[11
]}

Souchon, Rainer ^{[12
]}

Wenz, Frederik ^{[13
]}

Sauer, Rolf ^{[6
]}

机构：

[1] Univ Hosp Heidelberg, Dept Radiat Oncol, Neuenheimer Feld 400, D-69120 Heidelberg, Germany

[2] Natl Ctr Radiat Res Oncol NCRO, Heidelberg Inst Radiat Oncol, Heidelberg, Germany

[3] Univ Hosp Schleswig Holstein, Kiel, Germany

[4] Heinrich Heine Univ, Dusseldorf, Germany

[5] Vivantes Hosp Neukoelln, Berlin, Germany

[6] Univ Hosp Erlangen, Erlangen, Germany

[7] St Vincentius Hosp, Karlsruhe, Germany

[8] St Clara Hosp, Basel, Switzerland

[9] Marienhosp Stuttgart, Dept Radiat Oncol, Stuttgart, Germany

[10] Witten Herdecke Univ, HELIOS Hosp Wuppertal, Wuppertal, Germany

[11] Paracelsus Med Univ Hosp, Salzburg, Austria

[12] Univ Hosp Tuebingen, Tubingen, Germany

[13] Heidelberg Univ, Univ Med Mannheim, Med Fak Mannheim, D-GRID77000 Mannheim, Germany

来源：

STRAHLENTHERAPIE UND ONKOLOGIE | 2018年 / 194卷 / 07期

关键词：

Local recurrence; Neoadjuvant therapy; Breast neoplasms; Radiotherapy; INTERNATIONAL EXPERT PANEL; DEGRO PRACTICAL GUIDELINES; SURGICAL ADJUVANT BREAST; TUMORS; 5; CM; STAGE-II; RADIATION-THERAPY; LOCOREGIONAL RECURRENCE; SYSTEMIC TREATMENT; LYMPH-NODES; MULTICENTER;

D O I：

10.1007/s00066-018-1270-x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To review the evidence regarding post-mastectomy radiotherapy (PMRT) and regional nodal irradiation (RNI) after neoadjuvant chemotherapy (NACT) for breast cancer, with a special focus on individualization of adjuvant radiotherapy based on treatment response. A systematic literature search using the PubMed/Medline database was performed. We included prospective and retrospective reports with a minimum of 10 patients that had been published since 1(st) January 2000, and provided clinical outcome data analyzed by treatment response and radiotherapy. Out of 763 articles identified via PubMed/Medline and hand search, 68 full text-articles were assessed for eligibility after screening of title and abstract. 13 studies were included in the systematic review, 9 for PMRT and 5 for RNI. All included studies were retrospective reports. There is a considerable lack of evidence regarding the role of adjuvant radiotherapy and its individualization based on treatment response after NACT. Results of prospective randomized trials such as NSABP BaEuro51/RTOG 1304 and Alliance A11202 are eagerly awaited.

引用

页码：607 / 618

页数：12

共 50 条

[1] Individualization of post-mastectomy radiotherapy and regional nodal irradiation based on treatment response after neoadjuvant chemotherapy for breast cancer-a systematic review
Krug, D.
Baumann, R.
Budach, W.
Dunst, J.
Feyer, P.
Fietkau, R.
Haase, W.
Harms, W.
Hehr, T.
Piroth, M. D.
Sedlmayer, F.
Souchon, R.
Wenz, F.
Sauer, R.
STRAHLENTHERAPIE UND ONKOLOGIE, 2018, 194 : S142 - S143
[2] ASO Author Reflections: Residual Disease in the Breast After Neoadjuvant Chemotherapy Does Not Mandate Routine Post-Mastectomy Radiation Therapy/Regional Nodal Irradiation
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[3] Post-mastectomy radiotherapy after neodjuvant chemotherapy in breast cancer patients: A review
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[4] Individualization of post-mastectomy radiotherapy and regional nodal irradiation based on treatment response after neoadjuvant chemotherapy for breast cancer: A systematic review; [Individualisierung von Post-Mastektomie-Radiotherapie und regionärer Lymphknotenbestrahlung anhand des Therapieansprechens nach neoadjuvanter Chemotherapie bei Brustkrebs: Ein systematischer Review]
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Souchon R.
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[5] ASO Author Reflections: Residual Disease in the Breast After Neoadjuvant Chemotherapy Does Not Mandate Routine Post-Mastectomy Radiation Therapy/Regional Nodal Irradiation
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[6] Post-Mastectomy Hypofractionated Radiotherapy for Breast Cancer Treatment
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[9] The Impact of Post-Mastectomy Radiotherapy on Survival Outcomes in Breast Cancer Patients Who Underwent Neoadjuvant Chemotherapy
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