Central nervous system involvement in primary Sjogren's syndrome manifesting as multiple sclerosis

Central nervous system symptoms in patients with primary Sjogren's syndrome are rare. They can present as extraglandular manifestations and require a differential diagnosis from multiple sclerosis. Due to a variety of presentations, Sjogren's syndrome with neurologic involvement may be difficult to diagnose. Here, we report a case of a 75-year-old woman who was first diagnosed with multiple sclerosis in 2010, but who was subsequently diagnosed with primary Sjogren's syndrome 2 years later after showing signs of atypical neurologic manifestations. Therefore, primary Sjogren's syndrome should be suspected in patients who present with atypical clinical and radiologic neurologic manifestations.