Synthesis of new fluorinated 1,5-benzoxazepine derivatives

被引：13
|
作者：
Cocco, MT [1 ]
Congiu, C [1 ]
Onnis, V [1 ]
Bernard, AM [1 ]
Piras, PP [1 ]
机构：
[1] UNIV CAGLIARI,DIPARTIMENTO SCI CHIM,I-09124 CAGLIARI,ITALY
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 1997年 / 34卷 / 04期
关键词：
D O I：
10.1002/jhet.5570340442
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple approach to the fluorinated 1,5-benzoxazepine ring system is described. By reacting commercially accessible aminophenols 1 and the trifluoroacetylvinyl ether 2, high yields of enaminones 3 were obtained. Functionalization of methyl group of compounds 3 gave rise to dieneamines 4 that were cyclized in acidic environment to benzoxazepine derivatives 5.
引用
收藏
页码：1347 / 1350
页数：4
相关论文
共 50 条
  • [21] Synthesis of New Fluorinated Podophyllotoxin Derivatives
    Xue Ying HE
    Chinese Chemical Letters, 2004, (02) : 131 - 134
  • [22] SYNTHESIS OF BENZOXAZEPINE DERIVATIVES .6. ANTHRACENOOXAZEPINES
    PECHER, J
    WAEFELAER, A
    BULLETIN DES SOCIETES CHIMIQUES BELGES, 1978, 87 (11-1): : 911 - 915
  • [23] Synthesis of isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine: two new ring systems of pharmaceutical interest
    Parrino, Barbara
    Ciancimino, Cristina
    Carbone, Anna
    Spano, Virginia
    Montalbano, Alessandra
    Barraja, Paola
    Cirrincione, Girolamo
    Diana, Patrizia
    TETRAHEDRON, 2015, 71 (39) : 7332 - 7338
  • [24] Synthesis of novel fluorinated 1,5-benzothiazepine derivatives and their biological evaluation as anticancer and antibacterial agents
    Bhabal, Sonal
    Shaikh, Sarfaraz
    Yellapurkar, Ishita
    Pavale, Ganesh
    Ramana, Mucheli
    JOURNAL OF THE SERBIAN CHEMICAL SOCIETY, 2022, 87 (10) : 1109 - 1116
  • [25] SYNTHESIS OF BENZOXAZEPINE DERIVATIVES .3. ISOINDOLINONES
    PECHER, J
    WAEFELAER, A
    POULTIER, P
    BULLETIN DES SOCIETES CHIMIQUES BELGES, 1977, 86 (12): : 1003 - 1007
  • [26] Synthesis of new sulfapyrimidine and pyrazolo[1,5-a]pyrimidine derivatives
    Ahmed, Ebtsam A. A.
    Elgemeie, Galal H. H.
    Azzam, Rasha A. A.
    SYNTHETIC COMMUNICATIONS, 2023, 53 (05) : 386 - 401
  • [27] Synthesis and stereostructure of new β-lactam derivatives of 1,5-benzothiazepines
    Li, Y
    Sun, N
    Jin, S
    CHINESE CHEMICAL LETTERS, 1999, 10 (06) : 447 - 448
  • [28] Synthesis and evaluation of some new substituted benzothiazepine and benzoxazepine derivatives as anticonvulsant agents
    Garg, Neha
    Chandra, Trilok
    Archana
    Jain, Amit B.
    Kumar, Ashok
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (04) : 1529 - 1535
  • [29] Synthesis of new phosphonic derivatives with fluorinated chains
    Brondino, C
    Boutevin, B
    Hervaud, Y
    Pelaprat, N
    Manseri, A
    JOURNAL OF FLUORINE CHEMISTRY, 1996, 76 (02) : 193 - 200
  • [30] Synthesis of new fluorinated derivatives of quinolinecarboxylic acids
    Nosova E.V.
    Sidorova L.P.
    Lipunova G.N.
    Mochul'skaya N.N.
    Chasovskikh O.M.
    Charushin V.N.
    Chemistry of Heterocyclic Compounds, 2002, 38 (08) : 922 - 928
12345