Synthesis of new fluorinated 1,5-benzoxazepine derivatives

被引：13
|
作者：
Cocco, MT [1 ]
Congiu, C [1 ]
Onnis, V [1 ]
Bernard, AM [1 ]
Piras, PP [1 ]
机构：
[1] UNIV CAGLIARI,DIPARTIMENTO SCI CHIM,I-09124 CAGLIARI,ITALY
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 1997年 / 34卷 / 04期
关键词：
D O I：
10.1002/jhet.5570340442
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple approach to the fluorinated 1,5-benzoxazepine ring system is described. By reacting commercially accessible aminophenols 1 and the trifluoroacetylvinyl ether 2, high yields of enaminones 3 were obtained. Functionalization of methyl group of compounds 3 gave rise to dieneamines 4 that were cyclized in acidic environment to benzoxazepine derivatives 5.
引用
收藏
页码：1347 / 1350
页数：4
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