The genome sequence of Drosophila melanogaster

被引：4532
|
作者：
Adams, MD
Celniker, SE
Holt, RA
Evans, CA
Gocayne, JD
Amanatides, PG
Scherer, SE
Li, PW
Hoskins, RA
Galle, RF
George, RA
Lewis, SE
Richards, S
Ashburner, M
Henderson, SN
Sutton, GG
Wortman, JR
Yandell, MD
Zhang, Q
Chen, LX
Brandon, RC
Rogers, YHC
Blazej, RG
Champe, M
Pfeiffer, BD
Wan, KH
Doyle, C
Baxter, EG
Helt, G
Nelson, CR
Miklos, GLG
Abril, JF
Agbayani, A
An, HJ
Andrews-Pfannkoch, C
Baldwin, D
Ballew, RM
Basu, A
Baxendale, J
Bayraktaroglu, L
Beasley, EM
Beeson, KY
Benos, PV
Berman, BP
Bhandari, D
Bolshakov, S
Borkova, D
Botchan, MR
Bouck, J
Brokstein, P
机构：
[1] Celera Genom, Rockville, MD 20850 USA
[2] Univ Calif Berkeley, Lawrence Berkeley Lab, BDGP, Berkeley, CA 94720 USA
[3] Baylor Coll Med, Dept Mol & Human Genet, Human Genome Sequencing Ctr, Houston, TX 77030 USA
[4] Univ Calif Berkeley, Dept Cell & Mol Biol, BDGP, Berkeley, CA 94720 USA
[5] European Mol Biol Lab, European Bioinformat Inst, Cambridge CB10 1SD, England
[6] Neomorph Inc, Berkeley, CA 94710 USA
[7] Genetixxpress Pty Ltd, Sydney, NSW 2108, Australia
[8] IMIM UPF, Dept Med Informat, Barcelona 08003, Spain
[9] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA
[10] Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA
[11] FORTH, Inst Mol Biol & Biotechnol, Iraklion, Greece
[12] EMBL, EDGP, Heidelberg, Germany
[13] Univ Calif Berkeley, Dept Cell & Mol Biol, Berkeley, CA 94710 USA
[14] Genoscope, F-91000 Evry, France
[15] Univ Calif Davis, Sect Mol & Cellular Biol, Davis, CA 95618 USA
[16] Univ Cambridge, Dept Genet, Cambridge CB2 3EH, England
[17] Univ Rennes 2, Fac Med, Sch Med, EDGP,CNRS,UPR 41, F-35043 Rennes, France
[18] Stanford Univ, Dept Genet, Stanford, CA 94305 USA
[19] Univ Calif Berkeley, Dept Stat, Berkeley, CA 94720 USA
[20] Univ Autonoma Madrid, CSIC, Ctr Biol Mol Severo Ochoa, EDGP, E-28049 Madrid, Spain
[21] Salk Inst Biol Studies, Mol Biol & Virol Lab, La Jolla, CA 92037 USA
[22] Univ Arizona, Dept Biochem, Tucson, AZ 85721 USA
[23] Univ Arizona, Ctr Insect Sci, Tucson, AZ 85721 USA
[24] Univ Montpellier, Sch Med, EDGP, Inst Genet Humaine,CNRS,CRBM, F-34396 Montpellier 5, France
[25] NICHHD, Mol Genet Lab, NIH, Bethesda, MD 20892 USA
[26] McGill Univ, Dept Biol, Montreal, PQ H3A 1B1, Canada
[27] Univ Maryland, Dept Cell Biol & Mol Genet, College Pk, MD 20742 USA
[28] Inst Genom Res, Rockville, MD 20850 USA
[29] Sanger Ctr, EDGP, Cambridge CB10 1SA, England
[30] Univ Tennessee, Dept Biochem, Memphis, TN 38163 USA
[31] Univ Dundee, Dept Anat & Physiol, EDGP, Dundee DD1 4HN, Scotland
[32] Open Univ, Dept Biol Sci, Milton Keynes MK7 6AA, Bucks, England
[33] Carnegie Inst Sci, HHM Embryol, Baltimore, MD 21210 USA
[34] Motorola Biochip Syst, Tempe, AZ 85284 USA
[35] NICHHD, Cell Biol & Metab Branch, NIH, Bethesda, MD 20892 USA
[36] Univ Calif Berkeley, Howard Hughes Med Inst, BDGP, Berkeley, CA 94720 USA
来源：
SCIENCE | 2000年 / 287卷 / 5461期
关键词：
D O I：
10.1126/science.287.5461.2185
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The fly Drosophila melanogaster is one of the most intensively studied organisms in biology and serves as a model system for the investigation of many developmental and cellular processes common to higher eukaryotes, including humans. We have determined the nucleotide sequence of nearly all of the similar to 120-megabase euchromatic portion of the Drosophila genome using a whole-genome shotgun sequencing strategy supported by extensive clone-based sequence and a high-quality bacterial artificial chromosome physical map. Efforts are under way to close the remaining gaps; however, the sequence is of sufficient accuracy and Contiguity to be declared substantially complete and to support an initial analysis of genome structure and preliminary gene annotation and interpretation. The genome encodes similar to 13,600 genes, somewhat fewer than the smaller Caenorhabditis elegans genome, but with comparable functional diversity.
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页码：2185 / 2195
页数：11
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