Discovery of new anti-inflammatory agents

被引：12
|
作者：
Fülöp, F
Lázár, L
Szakonyi, Z
Pihlavisto, M
Alaranta, S
Vainio, PJ
Juhakoski, A
Marjamäki, A
Smith, DJ
机构：
[1] Univ Szeged, Inst Pharmaceut Chem, H-6720 Szeged, Hungary
[2] Biotie Therapies Corp, FIN-20520 Turku, Finland
来源：
PURE AND APPLIED CHEMISTRY | 2004年 / 76卷 / 05期
关键词：
D O I：
10.1351/pac200476050965
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We have synthesized a series of novel hydrazines and hydrazino alcohols that specifically inhibit vascular adhesion protein-1 (VAP-1), a human endothelial cell adhesion molecule with a well-documented role in inflammation. VAP-1 is a semicarbazide-sensitive amine oxidase (SSAO), and the enzyme activity has been demonstrated to have a role in VAP-1 function. An indane hydrazino alcohol was able to reduce clinical symptoms of inflammation in experimental arthritis in rodents and has the potential to be a novel anti-inflammatory drug.
引用
收藏
页码：965 / 972
页数：8
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