Chemical Synthesis of U1 snRNA Derivatives

被引：14

作者：

Ohkubo, Akihiro ^{[1
]}

Kondo, Yasushi ^{[2
]}

Suzuki, Makoto ^{[1
]}

Kobayashi, Haruki ^{[1
]}

Kanamori, Takashi ^{[1
]}

Masaki, Yoshiaki ^{[1
]}

Seio, Kohji ^{[1
]}

Nagai, Kiyoshi ^{[2
]}

Sekine, Mitsuo ^{[1
]}

机构：

[1] Tokyo Inst Technol, Dept Life Sci, Midori Ku, Yokohama, Kanagawa 2268501, Japan

[2] MRC Lab Mol Biol, Cambridge CB2 0QH, England

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 17期

关键词：

PRE-MESSENGER-RNA; NUCLEAR IMPORT; OLIGORIBONUCLEOTIDE; GENE;

D O I：

10.1021/ol401917r

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

U1 snRNA is an interesting biological tool for splicing correction and regulation of gene expression. However, U1 snRNA has never been chemically synthesized. In this study, the first chemical synthesis of U1snRNA and its analogues was carried out. Moreover, it was found that the binding affinity of the modified U1 snRNA with an ethylene glycol linkage to snurportin 1 (nuclear import adaptor) was as high as that of the unmodified RNA.

引用

页码：4386 / 4389

页数：4

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