BAP1 in solid tumors

被引：20

作者：

Di Nunno, Vincenzo ^{[1
]}

Frega, Giorgio ^{[2
]}

Santoni, Matteo ^{[3
]}

Gatto, Lidia ^{[2
]}

Fiorentino, Michelangelo ^{[4
]}

Montironi, Rodolfo ^{[5
]}

Battelli, Nicola ^{[3
]}

Brandi, Giovanni ^{[2
]}

Massari, Francesco ^{[1
]}

机构：

[1] St Orsola Marcello Malpighi Hosp, Div Oncol, Bologna, Italy

[2] Univ Bologna, St Orsola Malpighi Hosp, Dept Expt Diagnost & Specialty Med, Oncol Unit, Bologna, Italy

[3] Macerata Hosp, Dept Oncol, Macerata, Italy

[4] St Orsola Marcello Malpighi Hosp, Addarii Inst Oncol, Pathol Serv, Bologna, Italy

[5] Polytech Univ Marche Reg, Sch Med, Sect Pathol Anat, United Hosp, Ancona, Italy

来源：

FUTURE ONCOLOGY | 2019年 / 15卷 / 18期

关键词：

BAP1; cholangiocarcinoma; melanoma; mesothelioma; renal cell carcinoma; thymic carcinoma; HISTONE DEACETYLASE INHIBITOR; RENAL-CELL CARCINOMA; BRCA1-ASSOCIATED PROTEIN-1; INTRAHEPATIC CHOLANGIOCARCINOMA; MUTATIONS PREDISPOSE; PHASE-II; MESOTHELIOMA; ASBESTOS; CANCER; DIAGNOSIS;

D O I：

10.2217/fon-2018-0915

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

One of the most attractive cancer-related genes under investigation is BAP1. Reasons of this growing interest are related to the wide spectrum of pathways directly or indirectly modulated by this gene and shared by several solid tumors. Programmed cell-death, cell metabolisms, immune cells development, ferroptosis and defects in DNA damage response are only some of the multitude of processes depending on BAP1. Loss of this gene seems to occur in different times of tumor history. Moreover, times of BAP1 loss strongly diverge among primary tumors suggesting the presence of several and different triggering factors. Regardless of when it happens, BAP1 loss usually results in prognosis worsening and in the acquisition of more aggressive clinical features by cancer cells.

引用

页码：2151 / 2162

页数：12

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