Induction of GM-CSF production of macrophages by advanced glycation end products of the Maillard reaction

被引:11
|
作者
Sasaki, T
Horiuchi, S
Yamazaki, M
Yui, S [1 ]
机构
[1] Teikyo Univ, Fac Pharmaceut Sci, Sagamiko, Kanagawa 1990195, Japan
[2] Kumamoto Univ, Sch Med, Dept Biochem, Kumamoto 8600811, Japan
关键词
GM-CSF; advanced glycation end products; macrophage growth;
D O I
10.1271/bbb.63.2011
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We previously reported that AGEs can induce macrophage growth. In this paper, we examined whether advanced glycation end products (AGE) of protein induced GM-CSF production of macrophages. AGE of bovine serum albumin markedly stimulated not only the expression of GM-CSF mRNA, but also GM-CSF secretion in macrophage supernatant. Thus GM-CSF is suggested to be an endogenous signal for macrophage growth induction by AGEs.
引用
收藏
页码:2011 / 2013
页数:3
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