Hypericum perforatum methanolic extract inhibits growth of human prostatic carcinoma cell line orthotopically implanted in nude mice

被引：35
|
作者：
Martarelli, D
Martarelli, B
Pediconi, D
Nabissi, MI
Perfumi, M
Pompei, P
机构：
[1] Univ Camerino, Dept Pharmacol Sci & Expt Med, I-62032 Camerino, MC, Italy
[2] Dept Morphol Sci & Comparat Biochem, I-62032 Camerino, Italy
[3] Biosistema Srl, I-62032 Camerino, Italy
来源：
CANCER LETTERS | 2004年 / 210卷 / 01期
关键词：
prostate cancer; Hypericum perforatum; serotonin; neuroendocrine differentiation;
D O I：
10.1016/j.canlet.2004.01.031
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The antiproliferative effect of serotonin-reuptake inhibitors (SSRI) and serotonin antagonists has been demonstrated in Prostate tumors. Since Hypericum perforatum components act as serotonin-reuptake inhibitors and exert cytotoxic effects on several human cancer cell lines, in this work we analyzed the effect of a treatment with Hypericumperforatum extract (HPE) on the growth of human prostate cancer cells in vitro and in vivo. This study highlighted a significant reduction of tumor growth and number of metastasis suggesting that this natural compound may be useful in the treatment of prostate cancer. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
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收藏
页码：27 / 33
页数：7
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