Visualization, documentation, analysis, and communication of large-scale gene regulatory networks

被引：68
|
作者：
Longabaugh, William J. R. [1 ]
Davidson, Eric H. [2 ]
Bolouri, Hamid [1 ,2 ]
机构：
[1] Inst Syst Biol, Seattle, WA 98103 USA
[2] CALTECH, Div Biol, Pasadena, CA 91125 USA
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS | 2009年 / 1789卷 / 04期
关键词：
Genetic regulatory network; Gene regulation; Systems biology; Modeling; Computational biology; REPRESENTATION; SOFTWARE; MODELS;
D O I：
10.1016/j.bbagrm.2008.07.014
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Genetic regulatory networks (GRNs) are complex, large-scale, and spatially and temporally distributed. These characteristics impose challenging demands on software tools for building GRN models, and so there is a need for custom tools. In this paper, we report on our ongoing development of BioTapestry, an open Source, freely available computational tool designed specifically for building GRN models. We also outline our future development plans, and give some examples Of Current applications of BioTapestry. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码：363 / 374
页数：12
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