Lipid Metabolites from the Mushroom Meripilus giganteus

被引:0
|
作者
Cateni, Francesca [1 ]
Altieri, Tiziano [2 ]
Zacchigna, Marina [1 ]
Procida, Giuseppe [1 ]
Zilic, Jelena [1 ]
Zigon, Dusan [3 ]
Cichelli, Angelo [4 ]
机构
[1] Univ Trieste, Dept Chem & Pharmaceut Sci, I-34127 Trieste, Italy
[2] Univ G dAnnunzio, Sci, I-66100 Chieti, Italy
[3] Jozef Stefan Inst, Dept Environm Sci, Ljubljana 1000, Slovenia
[4] Univ G dAnnunzio, DEC, Lab Commod Sci, I-65127 Pescara, Italy
关键词
Meripilus giganteus; Basidiomycetes; Mushroom; DPPH; Superoxide anion; CEREBROSIDES; ANTIOXIDANTS; ERGOSTEROL; CHEMISTRY; KARST;
D O I
暂无
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The phytochemical investigation of the methanolic extract of the white rot fungus Meripilus giganteus resulted in the isolation and identification of complex mixtures of free fatty acids (1), monoacylglycerols (2), cerebrosides (3), ergosterol (4) and ergosterol peroxide (5). The structures of the isolated lipid metabolites (1-5) were determined by chemical and spectroscopic methods. The antioxidant activity of the whole MeOH extract of the fungus was evaluated through in vitro model systems, such as 2,2-diphenyl-1-picrylhydrazyl (DPPH) and superoxide anion. In all two systems, the results indicated that the extract of the fungus showed the same free-radical-scavenging activity with SC50 data of 47.70 mu g/mL, compared with the positive control quercetin (DPPH assay). None of the isolated compounds (1-5) showed a significant activity. Compounds 2-4 were isolated from Meripilus giganteus for the first time.
引用
收藏
页码:1833 / 1838
页数:6
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