Serum Oxidative Stress Markers in Patients with Senile Cataract and Healthy Controls

Objective: To investigate the role of oxidative stress in patients with senile cataract. Study Design: Case-control study. Place and Duration of Study: North Khorasan University of Medical Sciences, Bojnurd, Iran, from 2014 to 2015. Methodology: Non-randomised sampling was conducted on 74 patients with senile cataract and 79 healthy people. The oxidative stress level, glutathione peroxidase (GPx) and superoxide dismutase (SOD) enzymes were measured in serum. The results were analysed using SPSS software and followed by t-test analysis. P<0.05 was considered to be significant. Results: The median activity of GPx and SOD antioxidant enzymes in patients with cataract, was higher than healthy people (p=0.018 and p<0.0001, respectively). Peroxide-antioxidant (PAB) levels in patients with cataract was significantly higher than in healthy people (p<0.0001). Conclusion: This study showed that despite the high level of oxidative stress in patients, the activity rate of GPx and SOD enzymes also increased.