Serum Oxidative Stress Markers in Patients with Senile Cataract and Healthy Controls

被引：2

作者：

Shahinfar, Javad ^{[1
]}

Keshavarzi, Zakieh ^{[2
]}

Ahmadi, Mojgan ^{[3
]}

Barzegar, Saeid ^{[4
]}

Asieh, Garivani ^{[5
]}

Abbaspour, Alireza ^{[6
]}

机构：

[1] North Khorasan Univ Med Sci, Sch Med, Dept Anesthesia, Bojnurd, Iran

[2] North Khorasan Univ Med Sci, Nat Prod & Med Plants Res Ctr, Bojnurd, Iran

[3] Payamnoor Univ, Dept Biol, Mashhad, Iran

[4] North Khorasan Univ Med Sci, Sch Med, Dept Biochem & Hematol, Bojnurd, Iran

[5] North Khorasan Univ Med Sci, Sch Med, Bojnurd, Iran

[6] North Khorasan Univ Med Sci, Sch Med, Dept Biochem, Bojnurd, Iran

来源：

JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN | 2018年 / 28卷 / 06期

关键词：

Cataract; Glutathione peroxidase; Superoxide dismutase; Oxidative stress; ANTIOXIDANT ENZYMES; LENS;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: To investigate the role of oxidative stress in patients with senile cataract. Study Design: Case-control study. Place and Duration of Study: North Khorasan University of Medical Sciences, Bojnurd, Iran, from 2014 to 2015. Methodology: Non-randomised sampling was conducted on 74 patients with senile cataract and 79 healthy people. The oxidative stress level, glutathione peroxidase (GPx) and superoxide dismutase (SOD) enzymes were measured in serum. The results were analysed using SPSS software and followed by t-test analysis. P<0.05 was considered to be significant. Results: The median activity of GPx and SOD antioxidant enzymes in patients with cataract, was higher than healthy people (p=0.018 and p<0.0001, respectively). Peroxide-antioxidant (PAB) levels in patients with cataract was significantly higher than in healthy people (p<0.0001). Conclusion: This study showed that despite the high level of oxidative stress in patients, the activity rate of GPx and SOD enzymes also increased.

引用

页码：448 / 451

页数：4

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