Latin American Association for the study of the liver (ALEH) practice guidance for the diagnosis and treatment of non-alcoholic fatty liver disease

被引：81

作者：

Pablo Arab, Juan ^{[1
]}

Dirchwolf, Melisa ^{[2
]}

Alvares-da-Silva, Mario Reis ^{[3
,4
,5
]}

Barrera, Francisco ^{[1
]}

Benitez, Carlos ^{[1
]}

Castellanos-Fernandez, Marlene ^{[6
]}

Castro-Narro, Graciela ^{[7
]}

Chavez-Tapia, Norberto ^{[8
]}

Chiodi, Daniela ^{[9
]}

Cotrim, Helma ^{[10
]}

Cusi, Kenneth ^{[11
]}

Marques Souza de Oliveira, Claudia Pinto ^{[12
]}

Diaz, Javier ^{[13
]}

Fassio, Eduardo ^{[14
]}

Gerona, Solange ^{[15
]}

Girala, Marcos ^{[16
]}

Hernandez, Nelia ^{[9
]}

Marciano, Sebastian ^{[17
]}

Masson, Walter ^{[18
]}

Mendez-Sanchez, Nahum ^{[8
]}

Leite, Nathalie ^{[19
,20
]}

Lozano, Adelina ^{[21
,22
]}

Padilla, Martin ^{[23
]}

Panduro, Arturo ^{[24
]}

Parana, Raymundo ^{[10
]}

Parise, Edison ^{[25
]}

Perez, Marlene ^{[26
]}

Poniachik, Jaime ^{[27
]}

Carlos Restrepo, Juan ^{[28
,29
]}

Ruf, Andres ^{[2
]}

Silva, Marcelo ^{[30
]}

Tagle, Martin ^{[31
]}

Tapias, Monica ^{[32
]}

Torres, Kenia ^{[26
]}

Vilar-Gomez, Eduardo ^{[33
]}

Costa Gil, Jose Eduardo ^{[34
]}

Gadano, Adrian ^{[17
]}

Arrese, Marco ^{[1
]}

机构：

[1] Pontificia Univ Catolica Chile, Dept Gastroenterol, Escuela Med, Santiago, Chile

[2] Hosp Privado Rosario, Serv Hepatol, Unidad Trasplante Hepat, Rosario, Santa Fe, Argentina

[3] Hosp Clin Porto Alegre, Hepatol Div, Porto Alegre, RS, Brazil

[4] Univ Fed Rio Grande do Sul, Sch Med, Porto Alegre, RS, Brazil

[5] Univ Fed Rio Grande do Sul, Grad Program Gastroenterol & Hepatol, Porto Alegre, RS, Brazil

[6] Natl Inst Gastroenterol, Dept Res & Teaching, Havana, Cuba

[7] Natl Inst Med Sci & Nutr Salvador Zubiran, Gastroenterol Dept, Mexico City, DF, Mexico

[8] Med Sur Clin & Fdn, Liver Res Unit, Mexico City, DF, Mexico

[9] Univ Republica, Hosp Clin, Fac Med, Montevideo, Uruguay

[10] Univ Fed Bahia, Sch Med, Salvador, BA, Brazil

[11] Univ Florida, Div Endocrinol Diabet & Metab, Gainesville, FL USA

[12] Univ Sao Paulo, Dept Gastroenterol, Clin Div, Hepatol Branch,Sch Med, Sao Paulo, Brazil

[13] Hosp Edgardo Rebagliati Martins, Dept Aparato Digest, EsSalud, Lima, Peru

[14] Hosp Nacl Prof Alejandro Posadas, Serv Gastroenterol, Secc Higado Vias Biliares & Pancreas, Buenos Aires, DF, Argentina

[15] Hosp Fuerzas Armadas, Liver Unit, Montevideo, Uruguay

[16] Hosp Clinicas, Asuncion, Paraguay

[17] Hosp Italiano Buenos Aires, Liver Unit, Buenos Aires, DF, Argentina

[18] Hosp Italiano Buenos Aires, Buenos Aires, DF, Argentina

[19] Univ Fed Rio de Janeiro, Internal Med Dept, Sch Med, Rio De Janeiro, Brazil

[20] Univ Fed Rio de Janeiro, Clementino Fraga Filho Univ Hosp, Rio De Janeiro, Brazil

[21] Hosp Nacl Arzobispo Loayza, Serv Gastroenterol, Unidad Higado, Lima, Peru

[22] Univ Peruana Cayetano Heredia, Lima, Peru

[23] Hosp Guillermo Almenara, Lima, Peru

[24] Civil Hosp Guadalajara, Dept Mol Biol Med, Guadalajara, Jalisco, Mexico

[25] Univ Fed Sao Paulo, Dept Gastroenterol, Sao Paulo, Brazil

[26] Hosp Gen Plaza Salud, Santo Domingo, Dominican Rep

[27] Hosp Clin Univ Chile, Secc Gastroenterol, Santiago, Chile

[28] Univ Antioquia, Hepatobiliary & Liver Transplant Program, Hosp Pablo Tobon Uribe, Medellin, Colombia

[29] Univ Antioquia UdeA, Fac Med, Grp Gastrohepatol, Medellin, Colombia

[30] Hosp Univ Austral, Hepatol & Liver Transplant Unit, Pilar, Argentina

[31] Univ Peruana Cayetano Heredia, Fac Med Alberto Hurtado, Lima, Peru

[32] Hosp Univ Fdn Santa Fe Bogota, Bogota, Colombia

[33] Indiana Univ Sch Med, Div Gastroenterol & Hepatol, Indianapolis, IN 46202 USA

[34] Univ Favaloro, Fac Ciencias Med, Buenos Aires, DF, Argentina

来源：

ANNALS OF HEPATOLOGY | 2020年 / 19卷 / 06期

关键词：

Steatosis; NAFLD; NASH; Fatty liver; Clinical practice guidance; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; MAFLD; Cirrhosis; HEPATOCELLULAR-CARCINOMA; CARDIOVASCULAR-DISEASE; VITAMIN-E; INSULIN-RESISTANCE; SCORING SYSTEM; NONINVASIVE DIAGNOSIS; ALCOHOL-CONSUMPTION; METABOLIC SYNDROME; FIBROSIS STAGE; STEATOHEPATITIS;

D O I：

10.1016/j.aohep.2020.09.006

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Non-alcoholic fatty liver disease (NAFLD) currently represents an epidemic worldwide. NAFLD is the most frequently diagnosed chronic liver disease, affecting 20-30% of the general population. Furthermore, its prevalence is predicted to increase exponentially in the next decades, concomitantly with the global epidemic of obesity, type 2 diabetes mellitus (T2DM), and sedentary lifestyle. NAFLD is a clinical syndrome that encompasses a wide spectrum of associated diseases and hepatic complications such as hepatocellular carcinoma (HCC). Moreover, this disease is believed to become the main indication for liver transplantation in the near future. Since NAFLD management represents a growing challenge for primary care physicians, the Asociacion Latinoamericana para el Estudio del Higado (ALEH) has decided to organize this Practice Guidance for the Diagnosis and Treatment of Non-Alcoholic Fatty Liver Disease, written by Latin-American specialists in different clinical areas, and destined to general practitioners, internal medicine specialists, endocrinologists, diabetologists, gastroenterologists, and hepatologists. The main purpose of this document is to improve patient care and awareness of NAFLD. The information provided in this guidance may also be useful in assisting stakeholders in the decision-making process related to NAFLD. Since new evidence is constantly emerging on different aspects of the disease, updates to this guideline will be required in future. (C) 2020 Published by Elsevier Espana, S.L.U. on behalf of Fundacion Cilnica Medica Sur, A.C.

引用

页码：674 / 690

页数：17

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