The next generation of antiemetics for the management of postoperative nausea and vomiting

被引：8
|
作者：
Tan, Hon Sen [1 ]
Dewinter, Geertrui [2 ]
Habib, Ashraf S. [3 ]
机构：
[1] KK Womens & Childrens Hosp, Dept Womens Anesthesia, 100 Bukit Timah Rd, Singapore 229899, Singapore
[2] Katholieke Univ Leuven, Univ Hosp, Dept Anaesthesiol, Herestr 49, B-3000 Leuven, Belgium
[3] Duke Univ, Med Ctr, Dept Anesthesiol, Div Womens Anesthesia, Box 3094, Durham, NC 27710 USA
来源：
BEST PRACTICE & RESEARCH-CLINICAL ANAESTHESIOLOGY | 2020年 / 34卷 / 04期
关键词：
palonosetron; aprepitant; rolapitant; amisulpride; CHEMOTHERAPY-INDUCED NAUSEA; PALONOSETRON-DEXAMETHASONE COMBINATION; NK1 RECEPTOR ANTAGONISTS; RANDOMIZED PHASE-III; DOUBLE-BLIND; NEUROKININ-1; RECEPTOR; INTRAVENOUS AMISULPRIDE; POSTDISCHARGE NAUSEA; HIGH-RISK; PREVENTION;
D O I：
10.1016/j.bpa.2020.11.004
中图分类号：
R614 [麻醉学];
学科分类号：
100217 ;
摘要：
Postoperative nausea and vomiting (PONV) afflict approximately 30% of patients overall and up to 80% of high-risk patients after surgery. Optimal pharmacological prophylaxis of PONV is challenging as it necessitates the consideration of PONV risk, drug efficacy, and potential adverse effects. Despite significant advances in our understanding of the pathophysiology and risk factors of PONV, its incidence has remained largely unchanged. Newer antiemetics have been introduced that may have improved safety profiles, longer duration of action, and better efficacy. This review aims to summarize the recent developments pertaining to these new agents and their potential application toward the management of PONV. (C) 2020 Elsevier Ltd. All rights reserved.
引用
收藏
页码：759 / 769
页数：11
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