Among the many neurodegenerative diseases caused by repeat expansions, spinocerebellar ataxia type 8 (SCA8) has been something of a puzzle. Now, a new study shows that the CTG/CAG expansion in ATXN8OS (formerly SCA8) is transcribed in both directions, raising the possibility that two molecular mechanisms contribute to disease.
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Harvard Univ, MIT, Sch Med, Harvard MIT Div Hlth Sci & Technol, Cambridge, MA 02139 USAHarvard Univ, MIT, Sch Med, Harvard MIT Div Hlth Sci & Technol, Cambridge, MA 02139 USA
Li, Matthew
Cima, Michael J.
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MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USAHarvard Univ, MIT, Sch Med, Harvard MIT Div Hlth Sci & Technol, Cambridge, MA 02139 USA
Cima, Michael J.
Milner, Danny A., Jr.
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Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USAHarvard Univ, MIT, Sch Med, Harvard MIT Div Hlth Sci & Technol, Cambridge, MA 02139 USA