Common genetic variants of the vitamin D binding protein (DBP) predict differences in response of serum 25-hydroxyvitamin D [25(OH)D] to vitamin D supplementation

被引：161
|
作者：
Fu, Lei [1 ,4 ]
Yun, Francisco [1 ]
Oczak, Marko [1 ]
Wong, Betty Y. L. [4 ]
Vieth, Reinhold [1 ,5 ]
Cole, David E. C. [1 ,2 ,3 ,4 ]
机构：
[1] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON M5G 1L5, Canada
[2] Univ Toronto, Dept Pediat Genet, Toronto, ON M5G 1L5, Canada
[3] Univ Toronto, Dept Med, Toronto, ON M5G 1L5, Canada
[4] Sunnybrook Hlth Sci Ctr, Dept Clin Pathol, Toronto, ON M4N 3M5, Canada
[5] Mt Sinai Hosp, Dept Pathol & Lab Med, Toronto, ON M5G 1X5, Canada
来源：
CLINICAL BIOCHEMISTRY | 2009年 / 42卷 / 10-11期
关键词：
Vitamin D binding protein; Single nucleotide polymorphisms; Genotype; Serum 25(OH)D; Vitamin D supplementation; PLASMA-CONCENTRATIONS; POSTMENOPAUSAL WOMEN; PARATHYROID-HORMONE; GC; 1,25-DIHYDROXYVITAMIN-D;
D O I：
10.1016/j.clinbiochem.2009.03.008
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Background: To determine the effect of vitamin D binding protein (DBP) genotypes on 25-hydroxyvitamin D [25(OH)D] changes with vitamin D supplements, we studied 98 adults receiving 600 or 4000 IU/d vitamin D-3 for one year. Methods: The DBP functional variant, T436K, was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: Mean 25(OH)D increases were 97% for TT (n=48) 151% for TK (n=31) and 307% (n=6) for KK genotypes (P=.004). Conclusions: As with baseline 25(OH)D, T436K genotype predicts 25(OH)D changes after long-term vitamin D supplementation. (C) 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
引用
收藏
页码：1174 / 1177
页数：4
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