EFFECT OF STARCH HYDROLYSATES IN THE PROCESS OF DISSOLUTION OF SOLIDS

被引：0
|
作者：
Belniak, Piotr [1 ]
Swlader, Katarzyna [1 ]
Szumilo, Michal [1 ]
Pietrzyk, Ewelina [1 ]
Poleszak, Ewa [1 ]
机构：
[1] Med Univ Lublin, Chair & Dept Appl Pharm, Fac Pharm, PL-20093 Lublin, Poland
来源：
ACTA POLONIAE PHARMACEUTICA | 2015年 / 72卷 / 04期
关键词：
starch hydrolysate; dissolution of solids; progesterone; ibuprofen; SOLUBILIZATION; PH;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The purpose of this work was to investigate the influence of starch hydrolysates in the dissolution process of the substance practically insoluble in water. Progesterone and ibuprofen were chosen as model substances. The study was conducted with a constant amount of the drug (25 mg/mL) or constant amount of starch hydrolysate (50 mg/mL). Next, the influence of ethanolic solutions (10-30% v/v) on solubility of drug was tested. The results confirm the possibility of using starch hydrolysate as a cheap and safe addition to increase the solubility of practically insoluble drugs.
引用
收藏
页码：785 / 789
页数：5
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