A combined multicomponent-acid catalyzed cyclization reaction as an efficient route to novel tricyclic pyrrolo[2,1-a]isoquinoline derivatives

被引：2
|
作者：
Ghandi, Mehdi [1 ]
Khodadadi, Meysam [1 ]
Abbasi, Alireza [1 ]
机构：
[1] Univ Tehran, Sch Chem, Coll Sci, Tehran, Iran
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2021年 / 58卷 / 02期
关键词：
LAMELLARIN-ALPHA; 20-SULFATE; TOPOISOMERASE-I; INHIBITOR; TRANSFORMATIONS; CASCADE;
D O I：
10.1002/jhet.4185
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple, new two-step procedure for the synthesis of novel tricyclic pyrrolo[2,1-a]isoquinoline derivatives is described. The initially prepared polysubstituted pyrroles obtained via the four-component condensation of arylglyoxals, cyclic 1,3-dicarbonyls, aminoacetaldehyde dimethyl acetal, and beta-keto esters subsequently underwent intramolecular acid-catalyzed cyclization to the desired products in moderate to good yields.
引用
收藏
页码：478 / 487
页数：10
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