Glutathione S-transferase activity and glutathione content in human bladder carcinoma associated with schistosomiasis: Comparison with uninvolved surrounding tissues

被引：6
|
作者：
Hassan, AAM
Tagliabue, G
Codegoni, AM
DIncalci, M
ElSewedy, SM
Airoldi, L
机构：
[1] IST RIC FARMACOL MARIO NEGRI,MOL TOXICOL LAB,I-20157 MILAN,ITALY
[2] INST MED RES,ALEXANDRIA 21561,EGYPT
[3] IST RIC FARMACOL MARIO NEGRI,LAB CANC PHARMACOL,I-20157 MILAN,ITALY
来源：
CANCER LETTERS | 1997年 / 121卷 / 01期
关键词：
bladder neoplasms; schistosomiasis; glutathione transferases; glutathione;
D O I：
10.1016/S0304-3835(97)00314-5
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Glutathione (GSH), glutathione S-transferase (GST) activity and GST pi expression were measured in 10 human bladder tumors and adjacent uninvolved specimens from Egyptian patients with a history of schistosomal infection. GSH was higher in the tumor than in surrounding uninvolved tissue (not significant). Total GST activity per mg tissue protein and GST pi expression were higher in tumor tissues (P < 0.05) than in uninvolved tissues. There was a positive correlation between GST activity and GSH content and between total GST activity and GST pi expression in both tumor and uninvolved tissues. (C) 1997 Elsevier Science Ireland.
引用
收藏
页码：19 / 23
页数：5
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