Improvements in the Acylation of 3-Methylindole Using Amberlyst-15

被引：1
|
作者：
Vargas, Dario A. [1 ]
Mendez, Leticia J. [1 ,2 ]
Canepa, Alicia S. [1 ]
机构：
[1] Univ Nacl La Plata, Ctr Estudio Compuestos Organ CEDECOR, Dept Quim, Fac Ciencias Exactas, Calle 47 & 115, RA-1900 La Plata, Argentina
[2] Univ Nacl La Plata, Ctr Invest & Desarrollo Ciencias Aplicadas Dr Jor, Calle 47 257, RA-1900 La Plata, Argentina
来源：
LETTERS IN ORGANIC CHEMISTRY | 2020年 / 17卷 / 11期
关键词：
Amberlyst 15,3-Methylindole; Acylation reaction; Friedel-Crafts; ketones; acylindoles; FRIEDEL-CRAFTS ACYLATION; RING-CLOSURE; INDOLES; EFFICIENT; CATALYST; ACID;
D O I：
10.2174/1570178617666200207110109
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and efficient methodology for Friedel-Crafts acylation of 3-methylindole using Amberlyst 15 resin as catalyst is described. This methodology shows good selectivity towards the formation of the products of 2-acylation, (3-methyl-1H-indol-2-yl)ketones. Several advantages can be ascribed to Amberlyst 15, among them; are the ease of handling, quick separation from the reaction mixture and minimum or no production of the chemical residues that must be eliminated. Besides, the catalyst can be easily recycled and reused with a minimal loss in activity through 6 reaction cycles. The catalyst was characterized by FT-IR spectroscopy and superficial acidity.
引用
收藏
页码：890 / 896
页数：7
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