Science process skills are closely related to science. One of way to practice science process skills to students is laboratory experiments. Its main activity involves various student activities such as designing experiments, assembling and using equipments, analyzing and predicting data. This study aims to describe the profile of practical implementation and problems of chemistry subject at senior high school in Tanjungpura. The survey using interviews, questionnaires and observations towards to the principal, teachers and student of senior high schools at Tanjung Pura. Survey data were analyzed descriptively. The results obtained show that the practical implementation have less good criteria based on the questionnaire responses of teachers and students. Some aspects that show fairly low percentage is the availability of time, equipment and materials, practical guidance. In addition to the motivational aspect from environment is less supportive practicum. The results also show that there were problem such as laboratory facilities that not utilized; limited school support, lacked laboratory management, low teacher teacher preparation, practical implementation is not helped by a laboratory technician. For next research, there are development of practical guidence and inovation of practical equipment.