Synthesis and biological evaluation of a novel ONS tridentate Schiff base bearing pyrimidine ring and some metal complexes

被引：20
|
作者：
Sonmez, Mehmet [1 ]
Sogukomerogullari, Hatice Gamze [1 ]
Oztemel, Feyza [1 ]
Berber, Ismet [2 ]
机构：
[1] Gaziantep Univ, Fac Sci & Arts, Dept Chem, TR-27310 Gaziantep, Turkey
[2] Sinop Univ, Fac Sci & Arts, Dept Biol, TR-57010 Sinop, Turkey
来源：
MEDICINAL CHEMISTRY RESEARCH | 2014年 / 23卷 / 07期
关键词：
Pyrimidine-2-thione; 5-Chloro-2-hydroxyacethophenone; Schiff base metal complexes; Biological studies; ANTIMICROBIAL ACTIVITY; N-AMINOPYRIMIDINE; ANTIBACTERIAL; DERIVATIVES; COPPER(II); LIGAND; NICKEL(II); COBALT(II); BEHAVIOR; ZINC(II);
D O I：
10.1007/s00044-014-0925-0
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The new Schiff base ligand (1-[[1-(5-chloro-2-hydroxyphenyl)ethyliden]amino]-4-phenyl-5-benzoyl-pyrimidine-2-thione) and its Cu(II), Co(II), Pd(II), and Mn(II) complexes were synthesized and characterized by elemental and molar conductance, UV-Vis, IR, NMR spectra, magnetic moment as well as mass spectra. While Pd(II) complexes exhibited square planar geometry, the others displayed octahedral geometry. The complexes showed nonelectrolytic behavior. All the compounds were evaluated for in vitro antimicrobial efficiency against Gram-positive bacteria, Gram-negative bacteria, and yeast using microdilution procedure. This study suggested that the [Co(L)(2)]center dot 3H(2)O (1b) and [Mn(L)(2)]center dot 2H(2)O (1d) complexes might be new potential antimicrobial substances against bacteria and fungi.
引用
收藏
页码：3451 / 3457
页数：7
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