Novel Enterobacter Lineage as Leading Cause of Nosocomial Outbreak Involving Carbapenemase-Producing Strains

被引：42

作者：

Beyrouthy, Racha ^{[1
,2
,3
,4
,5
]}

Barets, Marion ^{[6
]}

Marion, Elodie ^{[6
]}

Dananche, Cedric ^{[6
]}

Dauwalder, Olivier ^{[7
,8
]}

Robin, Frederic ^{[1
,2
,3
,4
,5
]}

Gauthier, Lauraine ^{[9
,10
]}

Jousset, Agnes ^{[9
,10
]}

Dortet, Laurent ^{[9
,10
]}

Guerin, Francois ^{[11
]}

Benet, Thomas ^{[6
,8
]}

Cassier, Pierre ^{[6
]}

Vanhems, Philippe ^{[6
,8
]}

Bonnet, Richard ^{[1
,2
,3
,4
,5
]}

机构：

[1] Ctr Hosp Univ, Clermont Ferrand, France

[2] Ctr Natl Reference Resistance Antibiot, Clermont Ferrand, France

[3] Univ Clermont Auvergne, Clermont Ferrand, France

[4] Inst Natl Sante & Rech Med, Clermont Ferrand, France

[5] INRA, Clermont Ferrand, France

[6] Hosp Civils Lyon, Hop Edouard Herriot, Lyon, France

[7] Hosp Civils Lyon, Groupement Hosp Est, Lyon, France

[8] Ctr Int Rech Infectiol, Lyon, France

[9] CHU Bicetre, Paris, France

[10] Ctr Natl Reference Associe Resistance Antibiot, Paris, France

[11] Ctr Hosp Univ, Caen, France

来源：

EMERGING INFECTIOUS DISEASES | 2018年 / 24卷 / 08期

关键词：

CLOACAE COMPLEX; PLASMID; IDENTIFICATION; RESISTANCE; BACTERIA; FRANCE; TRENDS;

D O I：

10.3201/eid2408.180151

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We investigated unusual carbapenemase-producing Enterobacter cloacae complex isolates (n = 8) in the novel sequence type (ST) 873, which caused nosocomial infections in 2 hospitals in France. Whole-genome sequence typing showed the 1-year persistence of the epidemic strain, which harbored a bla(VIM-4) ST1-IncHI2 plasmid, in 1 health institution and 2 closely related strains harboring bla(CTX-M-15) in the other. These isolates formed a new subgroup in the E. hormaechei metacluster, according to their hsp60 sequences and phylogenomic analysis. The average nucleotide identities, specific biochemical properties, and pangenomic and functional investigations of isolates suggested isolates of a novel species that had acquired genes associated with adhesion and mobility. The emergence of this novel Enterobacter phylogenetic lineage within hospitals should be closely monitored because of its ability to persist and spread.

引用

页码：1505 / 1515

页数：11

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