Who's in charge? Nuclear receptor coactivator and corepressor function in brain and behavior

被引：53
|
作者：
Tetel, Marc J. [1 ]
Auger, Anthony P. [2 ]
Charlier, Thierry D. [3 ]
机构：
[1] Wellesley Coll, Neurosci Program, Wellesley, MA 02481 USA
[2] Univ Wisconsin, Dept Psychol, Madison, WI 53706 USA
[3] Univ Liege, GIGA Neurosci, B-4000 Liege, Belgium
来源：
FRONTIERS IN NEUROENDOCRINOLOGY | 2009年 / 30卷 / 03期
基金：
美国国家卫生研究院; 美国国家科学基金会;
关键词：
Steroid receptor coactivator-1 (SRC-1); Steroid hormones; Estrogen receptor; Progestin receptor; Androgen receptor; Brain development; Sex behavior; Sexual differentiation; Acetylation; Methylation; CREB-BINDING-PROTEIN; ALPHA TRANSCRIPTIONAL ACTIVITY; MESSENGER-RIBONUCLEIC-ACID; STEROID-HORMONE RECEPTORS; HUMAN ESTROGEN-RECEPTOR; NON-GENOMIC ACTIONS; THYROID-HORMONE; N-COR; GENE-EXPRESSION; ER-ALPHA;
D O I：
10.1016/j.yfrne.2009.04.008
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Steroid hormones act in brain and throughout the body to regulate a variety of functions, including development, reproduction, stress and behavior. Many of these effects of steroid hormones are mediated by their respective receptors, which are members of the steroid/nuclear receptor superfamily of transcriptional activators. A variety of studies in cell lines reveal that nuclear receptor coregulators are critical in modulating steroid receptor-dependent transcription. Thus, in addition to the availability of the hormone and the expression of its receptor, nuclear receptor coregulators are essential for efficient steroid-dependent transactivation of genes. This review will highlight the importance of nuclear receptor coregulators in modulating steroid-dependent gene expression in brain and the regulation of behavior. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码：328 / 342
页数：15
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