Deciphering the mammary epithelial cell hierarchy

被引:73
|
作者
Stingl, John
Raouf, Afshin
Eirew, Peter
Eaves, Connie J.
机构
[1] Terry Fox Lab, Vancouver, BC V5Z 1L3, Canada
[2] British Columbia Canc Agcy, Vancouver, BC V5Z 4E6, Canada
[3] Univ Cambridge, Dept Pathol, Cambridge, England
关键词
mammary gland; stem cells; hematopoiesis; mammary repopulating units; transplants; progenitors; colony; forming cells; differentiation;
D O I
10.4161/cc.5.14.2983
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Clonal assays offer a powerful approach to dissecting the many events involved in the generation and maintenance of complex tissues from an undifferentiated stem cell pool. The application of such quantitative functional methodologies to studies of the hematopoietic system have been key to defining the hierarchy of progenitor subsets that reflect an irreversible stepwise process of lineage restriction. Recent studies now suggest that a similar paradigm applies to the normal mammary gland. The adult mouse mammary gland maintains a population of stem cells that generate biologically distinct and physically separable subpopulations of mammary epithelial progenitors which, in turn, generate terminally differentiated cells. Suggestive parallels between mouse and human mammary cells point to the likelihood that a similarly structured multi-step differentiation program characterizes the mammary gland from both species.
引用
收藏
页码:1519 / 1522
页数:4
相关论文
共 50 条
  • [31] Angiotensin modulates human mammary epithelial cell motility
    Piastowska-Ciesielska, Agnieszka Wanda
    Dominska, Kamila
    Nowakowska, Magdalena
    Gajewska, Malgorzata
    Gajos-Michniewicz, Anna
    Ochedalski, Tomasz
    JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, 2014, 15 (04) : 419 - 429
  • [32] A NOVEL SYSTEM FOR MAMMARY EPITHELIAL-CELL CULTURE
    MCGRATH, MF
    JOURNAL OF DAIRY SCIENCE, 1987, 70 (09) : 1967 - 1980
  • [33] Using Notches to Track Mammary Epithelial Cell Homeostasis
    Robinson, Gertraud W.
    CELL STEM CELL, 2008, 3 (04) : 359 - 360
  • [34] Culture models of human mammary epithelial cell transformation
    Stampfer, MR
    Yaswen, P
    JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, 2000, 5 (04) : 365 - 378
  • [35] Transferrin and prolactin transcytosis in the lactating mammary epithelial cell
    Ollivier-Bousquet, M
    JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, 1998, 3 (03) : 303 - 313
  • [36] Deciphering the Mammary Stem Cell Niche: A Role for Laminin-Binding Integrins
    Romagnoli, Mathilde
    Cagnet, Stephanie
    Chiche, Aurelie
    Bresson, Laura
    Baulande, Sylvain
    de la Grange, Pierre
    De Arcangelis, Adele
    Kreft, Maaike
    George-Labouesse, Elisabeth
    Sonnenberg, Arnoud
    Deugnier, Marie-Ange
    Raymond, Karine
    Glukhova, Marina A.
    Faraldo, Marisa M.
    STEM CELL REPORTS, 2019, 12 (04): : 831 - 844
  • [37] Mammary epithelial cell interactions with fibronectin stimulate epithelial-mesenchymal transition
    Park, J.
    Schwarzbauer, J. E.
    ONCOGENE, 2014, 33 (13) : 1649 - 1657
  • [38] Mammary epithelial cell interactions with fibronectin stimulate epithelial-mesenchymal transition
    J Park
    J E Schwarzbauer
    Oncogene, 2014, 33 : 1649 - 1657
  • [39] CELL-CELL INTERACTIONS PROMOTE MAMMARY EPITHELIAL-CELL DIFFERENTIATION
    LEVINE, JF
    STOCKDALE, FE
    JOURNAL OF CELL BIOLOGY, 1985, 100 (05): : 1415 - 1422
  • [40] Cell cycle regulation of mammary epithelial cell detachment by Staphylococcus aureus
    Zavizion, B
    Bramley, AJ
    Politis, I
    JOURNAL OF DAIRY RESEARCH, 1996, 63 (04) : 543 - 553