Coincidence of otx2 and BMP4 signaling correlates with Xenopus cement gland formation

被引:42
|
作者
Gammill, LS [1 ]
Sive, H [1 ]
机构
[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA
基金
美国国家科学基金会;
关键词
Xenopus; anterior; ectoderm; cement gland; neural; otx2; BMP4;
D O I
10.1016/S0925-4773(99)00342-1
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
We previously showed that otx2 activates ectopic formation of the Xenopus cement gland only in ventrolateral ectoderm, defining a region of the embryo permissive for cement gland formation. In this paper, we explore the molecular identity of this permissive area. One candidate permissive factor is BMP4, whose putative graded inhibition by factors such as noggin has been proposed to activate both cement gland and neural fates. Several lines of evidence are presented to suggest that BMP signaling and otx2 work together to activate cement gland formation. First, BMP4 is highly expressed in the cement gland primordium, together with otx2. Second, cement gland formation in isolated ectoderm is always accompanied by coexpression of otx2 and BMP4 RNA, whether cement gland is induced by otx2 or by the BMP protein inhibitor noggin. Third, BMP signaling can modulate otx2 activity, such that increasing BMP signaling preferentially inhibits neural induction by otx2, while decreasing BMP signaling prevents cement gland formation. In addition, we show that a hormone-inducible otx2 activates both ectopic neural and cement gland formation within the cement gland permissive region, in a pattern reminiscent of that found in the embryo. We discuss this observation in view of a model that BMP4 and otx2 work together to promote cement gland formation. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:217 / 226
页数:10
相关论文
共 50 条
  • [21] Concurrent BMP4 and Noggin signaling induces tumor formation by pluripotent muscle-derived cells
    Pollett, JB
    Olshanski, A
    Ghareibeh, B
    Corsi, K
    Usas, A
    Peng, H
    Huard, J
    MOLECULAR BIOLOGY OF THE CELL, 2004, 15 : 338A - 338A
  • [22] BMP4 signaling regulates formation of Hertwig’s epithelial root sheath during tooth root development
    Akihiro Hosoya
    Ji-Youn Kim
    Sung-Won Cho
    Han-Sung Jung
    Cell and Tissue Research, 2008, 333
  • [23] Canonical Wnt Signaling Suppresses BMP4 Accumulation from C3H10T1/2 Cells Transfected with BMP4 Expression Vector
    Kishimoto, K. N.
    Itoi, E.
    JOURNAL OF BONE AND MINERAL RESEARCH, 2008, 23 : S164 - S164
  • [24] BMP4 signaling regulates formation of Hertwig's epithelial root sheath during tooth root development
    Hosoya, Akihiro
    Kim, Ji-Youn
    Cho, Sung-Won
    Jung, Han-Sung
    CELL AND TISSUE RESEARCH, 2008, 333 (03) : 503 - 509
  • [25] Loss of BMP2 and BMP4 Signaling in the Dental Epithelium Causes Defective Enamel Maturation and Aberrant Development of Ameloblasts
    Reibring, Claes-Goran
    El Shahawy, Maha
    Hallberg, Kristina
    Harfe, Brian D.
    Linde, Anders
    Gritli-Linde, Amel
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (11)
  • [26] Regulation of gut and heart left-right asymmetry by context-dependent interactions between Xenopus Lefty and BMP4 signaling
    Branford, WW
    Essner, JJ
    Yost, HJ
    DEVELOPMENTAL BIOLOGY, 2000, 223 (02) : 291 - 306
  • [27] Tsukushi Modulates Xnr2, FGF and BMP Signaling: Regulation of Xenopus Germ Layer Formation
    Morris, Samantha A.
    Almeida, Alexandra D.
    Tanaka, Hideaki
    Ohta, Kunimasa
    Ohnuma, Shin-ichi
    PLOS ONE, 2007, 2 (10):
  • [28] Ni2+ treatment causes cement gland formation in ectoderm explants of Xenopus laevis embryo
    HUANG YONG
    XIAO YAN DING
    (Shanghai Institute of Cell Biology
    CellResearch, 1999, (01) : 71 - 76
  • [29] Ni2+ treatment causes cement gland formation in ectoderm explants of Xenopus laevis embryo
    Yong HUANG
    Xiao Yan DING
    Cell Research, 1999, 9 : 71 - 76
  • [30] Endogenous Bmp4 in myoblasts is required for myotube formation in C2C12 cells
    Umemoto, Takenao
    Furutani, Yuuma
    Murakami, Masaru
    Matsui, Tohru
    Funaba, Masayuki
    BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2011, 1810 (12): : 1127 - 1135