Papillary serous carcinoma of the ovary: An ultrastructural and immunohistochemical study

被引:10
|
作者
Suo, ZH [1 ]
Karbove, K
Trope, CG
Metodiev, K
Nesland, JM
机构
[1] Norwegian Radium Hosp, Dept Pathol, N-0310 Oslo, Norway
[2] Univ Oslo, Inst Canc Res, Oslo, Norway
[3] Med Univ, Dept Pathol, Varna Bulgaria, Bulgaria
[4] Norwegian Radium Hosp, Dept Gynecol, Oslo, Norway
[5] Med Univ, Dept Immunol & Microbiol, Varna Bulgaria, Bulgaria
关键词
BM28; c-erbB-2; EGFR; immunohistochemistry; Ki67; ultrastructure;
D O I
10.1080/01913120490475716
中图分类号
TH742 [显微镜];
学科分类号
摘要
Twenty-four patients with ovarian serous papillary carcinoma were enrolled in the present ultrastructural and immunohistochemical study. Immunohistochemistry was used to examine the status of proliferation activity with antibodies against Ki67 and BM28, and the status of EGFR family members with antibodies against EGFR, c-erbB-2, and c-erbB-4. Ultrastructurally, poorly differentiated tumors often revealed solid sheets of tumor cells with variable desmosomes, cell connection complexies, and microvilli. No mature cilia, which are often present in benign and borderline ovarian epithelial tumors, were seen in these 24 carcinomas. However, two poorly differentiated tumors demonstrated oligocilia. In addition, numerous secondary lysosomes and bizzare intracytoplasmic pseudocavities were more often present in the poorly differentiated tumors. Immunohistochemically, strong expressions of BM28 and Ki67 in more than 50% of the tumor cells were found in 12/15 (80%) and 11/15 (73%) of the poorly differentiated tumors, respectively, compared with 3/9 (33%) and 1/9 (11%) of the moderately differentiated tumors, respectively. Higher levels of EGFR and c-erbB-2 expressions were more often observed in the poorly differentiated tumors, compared with that in the moderately differentiated tumors. In conclusion, oligocilium, numerous secondary lysosomes, and bizarre intracytoplasmic inclusions are more often seen in poorly differentiated ovarian serous carcinomas. Poorly differentiated ovarian serous carcinomas express higher levels of Ki67, BM28, EGFR, and c-erbB-2 proteins.
引用
收藏
页码:141 / 147
页数:7
相关论文
共 50 条
  • [31] Epigenetic and Genetic Alterations in Low Grade Papillary Serous Carcinoma of the Ovary
    Abu Shahin, F.
    Ji, X.
    Hui, P.
    Abudul-Karim, F.
    Liu, W.
    Yang, B.
    MODERN PATHOLOGY, 2009, 22 : 205A - 205A
  • [32] Epigenetic and Genetic Alterations in Low Grade Papillary Serous Carcinoma of the Ovary
    Abu Shahin, F.
    Ji, X.
    Hui, P.
    Abudul-Karim, F.
    Liu, W.
    Yang, B.
    LABORATORY INVESTIGATION, 2009, 89 : 205A - 205A
  • [33] Radiological findings in serous surface papillary carcinoma of the ovary - Case reports
    Kim, SH
    Cho, JY
    Park, IA
    Kang, SB
    Lee, HP
    Han, MC
    ACTA RADIOLOGICA, 1997, 38 (05) : 847 - 849
  • [35] SMALL-CELL CARCINOMA OF THE OVARY - AN IMMUNOHISTOCHEMICAL AND ULTRASTRUCTURAL-STUDY WITH A REVIEW OF THE LITERATURE
    LIFSCHITZMERCER, B
    DAVID, R
    DHARAN, M
    CZERNOBILSKY, B
    VIRCHOWS ARCHIV A-PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY, 1992, 421 (03) : 263 - 270
  • [36] Brenner tumor of the ovary:: A comparative immunohistochemical and ultrastructural study with transitional cell carcinoma of the bladder
    Ordóñez, NG
    Mackay, B
    ULTRASTRUCTURAL PATHOLOGY, 2000, 24 (03) : 157 - 167
  • [37] Immunohistochemical comparison of primary peritoneal and primary ovarian serous papillary carcinoma
    Halperin, R
    Zehavi, S
    Hadas, E
    Habler, L
    Bukovsky, I
    Schneider, D
    INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, 2001, 20 (04) : 341 - 345
  • [38] Expression of PAX2 in papillary serous carcinoma of the ovary: immunohistochemical evidence of fallopian tube or secondary Mullerian system origin?
    Tong, Guo-Xia
    Chiriboga, Luis
    Hamele-Bena, Diane
    Borczuk, Alain C.
    MODERN PATHOLOGY, 2007, 20 (08) : 856 - 863
  • [39] Serous papillary cystadenocarcinoma in supernumerary ovary
    Nomelini, R. S.
    Oliveira, L. J. De C.
    Jammal, M. P.
    Adad, S. J.
    Murta, E. F. C.
    JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2013, 33 (03) : 324 - 324
  • [40] HYPERAMYLASEMIA WITH PAPILLARY SEROUS CYSTADENOCARCINOMA OF THE OVARY
    SCHLIKKER, I
    NAKAD, A
    GERBAUX, A
    AZZOUZI, K
    KADOU, J
    LEZAIRE, P
    JANSSEN, A
    PIESSEVAUX, H
    DIVE, C
    ACTA CLINICA BELGICA, 1989, 44 (04): : 255 - 258