Safe Clinical Use of Carbon Nanotubes as Innovative Biomaterials

被引：189

作者：

Saito, Naoto ^{[1
]}

Haniu, Hisao ^{[2
]}

Usui, Yuki ^{[2
,3
]}

Aoki, Kaoru ^{[2
]}

Hara, Kazuo ^{[2
]}

Takanashi, Seiji ^{[2
]}

Shimizu, Masayuki ^{[2
]}

Narita, Nobuyo ^{[2
]}

Okamoto, Masanori ^{[2
]}

Kobayashi, Shinsuke ^{[2
]}

Nomura, Hiroki ^{[2
]}

Kato, Hiroyuki ^{[2
]}

Nishimura, Naoyuki ^{[5
]}

Taruta, Seiichi ^{[4
]}

Endo, Morinobu ^{[3
,4
]}

机构：

[1] Shinshu Univ, Inst Biomed Sci, Matsumoto, Nagano 3908621, Japan

[2] Shinshu Univ, Sch Med, Dept Orthopaed Surg, Matsumoto, Nagano 3908621, Japan

[3] Shinshu Univ, Res Ctr Exot Nanocarbons, Nagano 3808553, Japan

[4] Shinshu Univ, Fac Engn, Nagano 3808553, Japan

[5] Nakashima Med Co Ltd, R&D Ctr, Kita Ku, Okayama 7011221, Japan

来源：

CHEMICAL REVIEWS | 2014年 / 114卷 / 11期

基金：

日本科学技术振兴机构;

关键词：

IN-VIVO BIOCOMPATIBILITY; ASBESTOS-LIKE PATHOGENICITY; BONE-TISSUE COMPATIBILITY; TERM-FOLLOW-UP; NF-KAPPA-B; DRUG-DELIVERY; OXIDATIVE STRESS; PROTEIN CORONA; MECHANICAL-PROPERTIES; CELLULAR UPTAKE;

D O I：

10.1021/cr400341h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Carbon nanotubes (CNT) are structurally described as sheets of six-membered carbon atom rings rolled up into cylinders. CNTs with only one layer are known as single-walled CNTs (SWCNT), and those with two or more layers are known as multi-walled CNTs (MWCNT). The reasons are that CNTs have useful electrical, thermal, and mechanical characteristics, and their base material performance can be improved by combination with other materials. A recent industrial application of CNTs as an electrode additive to lithium-ion batteries is based on their excellent electrical characteristics. One reason for the intense competition to find biomaterial applications of CNTs and for the great potential of CNTs to advance medical care is their small size, which makes them suitable to react with living organisms.

引用

页码：6040 / 6079

页数：40

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