Direct Synthesis of N,N-Disubstituted Formamides by Oxidation of Imines Using an HFIP/UHP System

被引：15
|
作者：
Llopis, Natalia [1 ,2 ]
Gisbert, Patricia [1 ,2 ]
Baeza, Alejandro [1 ,2 ]
机构：
[1] Univ Alicante, Fac Ciencias, Dept Quim Organ, E-03080 Alicante, Spain
[2] Univ Alicante, Fac Ciencias, Inst Sintesis Organ ISO, E-03080 Alicante, Spain
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 85卷 / 17期
关键词：
FLUORINATED ALCOHOLS; HYDROGEN-PEROXIDE; AMIDES; OXAZIRIDINES; TRANSAMIDATION; REARRANGEMENT; FORMYLATION; DERIVATIVES; EPOXIDATION; ACTIVATION;
D O I：
10.1021/acs.joc.0c01579
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The straightforward synthesis of N,N-disubstituted formamides using a combination of 1,1,1,3,3,3-hexafluoroispropanol (HFIP) and H2O2 is described. The unique features of HFIP allowed the utilization of a green oxidant such as H2O2, and the products, arising from an oxidation-rearrangement sequence, were obtained in good to high yields under smooth reaction conditions.
引用
收藏
页码：11072 / 11079
页数：8
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